J
Jun Seop Jeong
Researcher at Johns Hopkins University School of Medicine
Publications - 23
Citations - 3293
Jun Seop Jeong is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Proteome & SUMO protein. The author has an hindex of 16, co-authored 22 publications receiving 2934 citations. Previous affiliations of Jun Seop Jeong include North Carolina State University & Johns Hopkins University.
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Journal ArticleDOI
The genome sequence of the rice blast fungus Magnaporthe grisea
Ralph A. Dean,Nicholas J. Talbot,Daniel J. Ebbole,Mark L. Farman,Thomas K. Mitchell,Marc J. Orbach,Michael R. Thon,Resham Kulkarni,Resham Kulkarni,Jin-Rong Xu,Huaqin Pan,Nick D. Read,Yong-Hwan Lee,Ignazio Carbone,Doug Brown,Yeonyee Oh,Nicole M. Donofrio,Jun Seop Jeong,Darren M. Soanes,Slavica Djonovic,Elena A. Kolomiets,Cathryn J. Rehmeyer,Weixi Li,Michael W. Harding,Soonok Kim,Marc-Henri Lebrun,Heidi U. Böhnert,Sean J. Coughlan,Jonathan Butler,Sarah E. Calvo,Li-Jun Ma,Robert Nicol,Seth Purcell,Chad Nusbaum,James E. Galagan,Bruce W. Birren +35 more
TL;DR: The draft sequence of the M. grisea genome is reported, reflecting the clonal nature of this fungus imposed by widespread rice cultivation and analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease.
Journal ArticleDOI
Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling.
Shaohui Hu,Zhi Xie,Akishi Onishi,Xueping Yu,Lizhi Jiang,Jimmy Lin,Hee Sool Rho,Crystal Woodard,Hong Wang,Jun Seop Jeong,Shunyou Long,Xiaofei He,Herschel Wade,Seth Blackshaw,Jiang Qian,Heng Zhu +15 more
TL;DR: A combined bioinformatics and protein microarray-based strategy is used to systematically characterize the human protein-DNA interactome, identifying 17,718 PDIs between 460 DNA motifs predicted to regulate transcription and 4,191 human proteins of various functional classes.
Journal ArticleDOI
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Yingfei Wang,Ran An,Ran An,George K.E. Umanah,Hyejin Park,Kalyani Nambiar,Stephen M. Eacker,Bong Woo Kim,Lei Bao,Maged M. Harraz,Calvin Chang,Rong Chen,Jennifer E. Wang,Tae In Kam,Jun Seop Jeong,Zhi Xie,Stewart Neifert,Jiang Qian,Shaida A. Andrabi,Seth Blackshaw,Heng Zhu,Hongjun Song,Guo Li Ming,Valina L. Dawson,Ted M. Dawson +24 more
TL;DR: It is discovered that macrophage migration inhibitory factor (MIF) binds AIF and is required for parthanatos, and EndoG does not have an essential role in PARP-dependent chromatinolysis and cell death in mammals.
Journal ArticleDOI
Construction of human activity-based phosphorylation networks.
Robert H. Newman,Robert H. Newman,Jianfei Hu,Hee Sool Rho,Zhi Xie,Crystal Woodard,John Neiswinger,Christopher D.O. Cooper,Matthew D. Shirley,Hillary M. Clark,Shaohui Hu,Woochang Hwang,Jun Seop Jeong,George Wu,Jimmy Lin,Xinxin Gao,Qiang Ni,Renu Goel,Shuli Xia,Hongkai Ji,Kevin N. Dalby,Morris J. Birnbaum,Philip A. Cole,Stefan Knapp,Alexey G. Ryazanov,Donald J. Zack,Seth Blackshaw,Tony Pawson,Anne-Claude Gingras,Stephen Desiderio,Akhilesh Pandey,Benjamin E. Turk,Jin-Peng Zhang,Heng Zhu,Jiang Qian +34 more
TL;DR: These studies provide global insights into kinase‐mediated signaling pathways and promise to advance the understanding of cellular signaling processes in humans.
Journal ArticleDOI
Rapid identification of monospecific monoclonal antibodies using a human proteome microarray
Jun Seop Jeong,Lizhi Jiang,Edisa Albino,Josean Marrero,Hee Sool Rho,Jianfei Hu,Shaohui Hu,Carlos Vera,Diane Bayron-Poueymiroy,Zully Ann Rivera-Pacheco,Leonardo Ramos,Cecil Torres-Castro,Jiang Qian,Joseph Bonaventura,Jef D. Boeke,Wendy Y. Yap,Ignacio Pino,Daniel Eichinger,Heng Zhu,Seth Blackshaw +19 more
TL;DR: A streamlined strategy for the production of monospecific monoclonal antibodies that used immunization with live human cells and microarray-based analysis of antibody specificity as its central components was developed and it was shown that micro array- based analysis of antibodies specificity can be performed efficiently using a two-dimensional pooling strategy.