S
Stuart S. Levine
Researcher at Massachusetts Institute of Technology
Publications - 74
Citations - 23036
Stuart S. Levine is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Chromatin & Cellular differentiation. The author has an hindex of 35, co-authored 68 publications receiving 21221 citations. Previous affiliations of Stuart S. Levine include Harvard University.
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Journal ArticleDOI
Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage
Joseph A. Wamstad,Jeffrey M. Alexander,Rebecca Truty,Avanti Shrikumar,Fugen Li,Kirsten Eilertson,Huiming Ding,John N. Wylie,Alexander R. Pico,John A. Capra,Genevieve D. Erwin,Steven J. Kattman,Gordon Keller,Deepak Srivastava,Stuart S. Levine,Katherine S. Pollard,Alisha K. Holloway,Laurie A. Boyer,Benoit G. Bruneau +18 more
TL;DR: A novel preactivation chromatin pattern at the promoters of genes associated with heart development and cardiac function is discovered and forms a basis for understanding developmentally regulated chromatin transitions during lineage commitment and the molecular etiology of congenital heart disease.
Journal ArticleDOI
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
Stuart S. Levine,Alona Weiss,Hediye Erdjument-Bromage,Zhaohui Shao,Paul Tempst,Robert E. Kingston +5 more
TL;DR: A human Polycomb repressive complex from HeLa cells (hPRC-H) is purified that contains homologues of PcG proteins found in drosophila embryonic PRC1 (dPRC1) and is able to efficiently block remodeling of nucleosomal arrays through a mechanism that does not block the ability of nucleases to access and cleave the arrays.
Journal ArticleDOI
Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis
Kun Lu,Ryan Abo,Katherine Ann Schlieper,Michelle E. Graffam,Stuart S. Levine,John S. Wishnok,James A. Swenberg,Steven R. Tannenbaum,James G. Fox +8 more
TL;DR: These findings may provide novel insights regarding perturbations of the gut microbiome and its functions as a potential new mechanism by which arsenic exposure leads to or exacerbates human diseases.
Journal ArticleDOI
Single-cell transcriptomic profiling of the aging mouse brain.
Methodios Ximerakis,Scott Lipnick,Brendan T. Innes,Sean Simmons,Xian Adiconis,Danielle Dionne,Brittany A Mayweather,Lan Nguyen,Zachary Niziolek,Ceren Ozek,Vincent L. Butty,Ruth Isserlin,Sean M. Buchanan,Stuart S. Levine,Aviv Regev,Gary D. Bader,Joshua Z. Levin,Lee L. Rubin,Lee L. Rubin +18 more
TL;DR: A single-cell transcriptomic atlas of the aging mouse brain reveals coordinated and cell-type-specific aging signatures across multiple cell populations, and highlights key molecular processes, including ribosome biogenesis, underlying brain aging.
Journal ArticleDOI
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.
Menno P. Creyghton,Styliani Markoulaki,Stuart S. Levine,Jacob H. Hanna,Michael A. Lodato,Ky Sha,Richard A. Young,Rudolf Jaenisch,Laurie A. Boyer +8 more
TL;DR: Genome-wide analysis reveals that H2AZ occupies the promoters of developmentally important genes in a manner that is remarkably similar to that of the Polycomb group (PcG) protein Suz12, and finds that H 2AZ and PcG protein occupancy is interdependent at promoters, and shows that H1AZ is necessary for ES cell differentiation.