S
Susan E. Ptak
Researcher at Max Planck Society
Publications - 15
Citations - 2405
Susan E. Ptak is an academic researcher from Max Planck Society. The author has contributed to research in topics: Population & Recombination. The author has an hindex of 13, co-authored 15 publications receiving 2312 citations.
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Journal ArticleDOI
Analysis of one million base pairs of Neanderthal DNA
Richard E. Green,Johannes Krause,Susan E. Ptak,Adrian W. Briggs,Michael T. Ronan,Jan Fredrik Simons,Lei Du,Michael Egholm,Jonathan M. Rothberg,Maja Paunović,Svante Pääbo +10 more
TL;DR: A 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA is identified and it is revealed that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago.
Journal ArticleDOI
The bonobo genome compared with the chimpanzee and human genomes
Kay Prüfer,Kasper Munch,Ines Hellmann,Keiko Akagi,Jason R. Miller,Brian P. Walenz,Sergey Koren,Granger G. Sutton,Chinnappa D. Kodira,Roger Winer,James R. Knight,James C. Mullikin,Stephen Meader,Chris P. Ponting,Gerton Lunter,Saneyuki Higashino,Asger Hobolth,Julien Y. Dutheil,Emre Karakoc,Can Alkan,Can Alkan,Saba Sajjadian,Claudia Rita Catacchio,Mario Ventura,Mario Ventura,Tomas Marques-Bonet,Tomas Marques-Bonet,Evan E. Eichler,Claudine André,Rebeca Atencia,Lawrence Mugisha,Jörg Junhold,Nick Patterson,Michael Siebauer,Jeffrey M. Good,Anne Fischer,Susan E. Ptak,Michael Lachmann,David E. Symer,Thomas Mailund,Mikkel H. Schierup,Aida M. Andrés,Janet Kelso,Svante Pääbo +43 more
TL;DR: The sequencing and assembly of the bonobo genome is reported to study its evolutionary relationship with the chimpanzee and human genomes, and it is found that more than three per cent of the human genome is more closely related to either theBonobo or the chimpanzees genome than these are to each other.
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A neutral explanation for the correlation of diversity with recombination rates in humans
TL;DR: It is shown that regions that experience less recombination have reduced divergence to chimpanzee and to baboon, as well as lower levels of diversity, which suggests that mutation and recombination are associated processes in humans, so that the positive correlation between diversity and recombinations may have a purely neutral explanation.
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Fine-scale recombination patterns differ between chimpanzees and humans
Susan E. Ptak,David A. Hinds,Kathrin Koehler,Birgit Nickel,Nila Patil,Dennis G. Ballinger,Molly Przeworski,Kelly A. Frazer,Svante Pääbo +8 more
TL;DR: Estimating recombination rates from 14 Mb of linkage disequilibrium data in central chimpanzee and human populations suggests that recombination hotspots are not conserved between the two species and that recombine rates in larger genomic regions are only weakly conserved.
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Why do human diversity levels vary at a megabase scale
TL;DR: It is found that measures of GC and CpG content, simple-repeat structures, as well as the distance from the centromeres and the telomeres predict diversity as wellAs divergence, and large-scale recombination rates measured from pedigrees are still significant predictors of human diversity and human-chimpanzee divergence.