M
Michael Siebauer
Researcher at Max Planck Society
Publications - 8
Citations - 4756
Michael Siebauer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Neanderthal genome project & Genome. The author has an hindex of 7, co-authored 8 publications receiving 4207 citations.
Papers
More filters
Journal ArticleDOI
The complete genome sequence of a Neanderthal from the Altai Mountains
Kay Prüfer,Fernando Racimo,Nick Patterson,Flora Jay,Sriram Sankararaman,Susanna Sawyer,Anja Heinze,Gabriel Renaud,Peter H. Sudmant,Cesare de Filippo,Heng Li,Swapan Mallick,Michael Dannemann,Qiaomei Fu,Martin Kircher,Martin Kuhlwilm,Michael Lachmann,Matthias Meyer,Matthias Ongyerth,Michael Siebauer,Christoph Theunert,Arti Tandon,Priya Moorjani,Joseph K. Pickrell,James C. Mullikin,Samuel H. Vohr,Richard E. Green,Ines Hellmann,Philip L. F. Johnson,Hélène Blanché,Howard M. Cann,Jacob O. Kitzman,Jay Shendure,Evan E. Eichler,Ed S. Lein,Trygve E. Bakken,Liubov V. Golovanova,Vladimir B. Doronichev,Michael V. Shunkov,A.P. Derevianko,Bence Viola,Montgomery Slatkin,David Reich,Janet Kelso,Svante Pääbo +44 more
TL;DR: It is shown that interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene and a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans is established.
Journal ArticleDOI
A high-coverage genome sequence from an archaic Denisovan individual
Matthias Meyer,Martin Kircher,Marie Theres Gansauge,Heng Li,Fernando Racimo,Swapan Mallick,Swapan Mallick,Joshua G. Schraiber,Flora Jay,Kay Prüfer,Cesare de Filippo,Peter H. Sudmant,Can Alkan,Can Alkan,Qiaomei Fu,Qiaomei Fu,Ron Do,Nadin Rohland,Nadin Rohland,Arti Tandon,Arti Tandon,Michael Siebauer,Richard E. Green,Katarzyna Bryc,Adrian W. Briggs,Udo Stenzel,Jesse Dabney,Jay Shendure,Jacob O. Kitzman,Michael F. Hammer,Michael V. Shunkov,A.P. Derevianko,Nick Patterson,Aida M. Andrés,Evan E. Eichler,Evan E. Eichler,Montgomery Slatkin,David Reich,David Reich,Janet Kelso,Svante Pääbo +40 more
TL;DR: The genomic sequence provides evidence for very low rates of heterozygosity in the Denisova, probably not because of recent inbreeding, but instead because of a small population size, and illuminates the relationships between humans and archaics, including Neandertals, and establishes a catalog of genetic changes within the human lineage.
Journal ArticleDOI
A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing
Richard E. Green,Anna-Sapfo Malaspinas,Johannes Krause,Adrian W. Briggs,Philip L. F. Johnson,Caroline Uhler,Matthias Meyer,Jeffrey M. Good,Tomislav Maricic,Udo Stenzel,Kay Prüfer,Michael Siebauer,Hernán A. Burbano,Michael T. Ronan,Jonathan M. Rothberg,Michael Egholm,Pavao Rudan,Dejana Brajković,Zeljko Kucan,Ivan Gušić,Mårten Wikström,Liisa Laakkonen,Janet Kelso,Montgomery Slatkin,Svante Pääbo +24 more
TL;DR: Analysis of the assembled sequence unequivocally establishes that the Neandertal mtDNA falls outside the variation of extant human mtDNAs, and allows an estimate of the divergence date between the two mtDNA lineages of 660,000 +/- 140,000 years.
Journal ArticleDOI
The bonobo genome compared with the chimpanzee and human genomes
Kay Prüfer,Kasper Munch,Ines Hellmann,Keiko Akagi,Jason R. Miller,Brian P. Walenz,Sergey Koren,Granger G. Sutton,Chinnappa D. Kodira,Roger Winer,James R. Knight,James C. Mullikin,Stephen Meader,Chris P. Ponting,Gerton Lunter,Saneyuki Higashino,Asger Hobolth,Julien Y. Dutheil,Emre Karakoc,Can Alkan,Can Alkan,Saba Sajjadian,Claudia Rita Catacchio,Mario Ventura,Mario Ventura,Tomas Marques-Bonet,Tomas Marques-Bonet,Evan E. Eichler,Claudine André,Rebeca Atencia,Lawrence Mugisha,Jörg Junhold,Nick Patterson,Michael Siebauer,Jeffrey M. Good,Anne Fischer,Susan E. Ptak,Michael Lachmann,David E. Symer,Thomas Mailund,Mikkel H. Schierup,Aida M. Andrés,Janet Kelso,Svante Pääbo +43 more
TL;DR: The sequencing and assembly of the bonobo genome is reported to study its evolutionary relationship with the chimpanzee and human genomes, and it is found that more than three per cent of the human genome is more closely related to either theBonobo or the chimpanzees genome than these are to each other.
Journal ArticleDOI
Patterns of coding variation in the complete exomes of three Neandertals
Sergi Castellano,Genís Parra,Federico Sánchez-Quinto,Fernando Racimo,Martin Kuhlwilm,Martin Kircher,Susanna Sawyer,Qiaomei Fu,Anja Heinze,Birgit Nickel,Jesse Dabney,Michael Siebauer,Louise White,Hernán A. Burbano,Gabriel Renaud,Udo Stenzel,Carles Lalueza-Fox,Marco de la Rasilla,Antonio Rosas,Pavao Rudan,Dejana Brajković,Željko Kućan,Ivan Gušić,Michael V. Shunkov,A.P. Derevianko,Bence Viola,Matthias Meyer,Janet Kelso,Aida M. Andrés,Svante Pääbo +29 more
TL;DR: It is shown that genetic diversity among Neandertals was remarkably low, and that they carried a higher proportion of amino acid-changing (nonsynonymous) alleles inferred to alter protein structure or function than present-day humans.