S
Susan L. Morris-Natschke
Researcher at University of North Carolina at Chapel Hill
Publications - 287
Citations - 9762
Susan L. Morris-Natschke is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cytotoxicity & Camptothecin. The author has an hindex of 48, co-authored 284 publications receiving 8331 citations. Previous affiliations of Susan L. Morris-Natschke include China Medical University (Taiwan) & Shandong University.
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Journal ArticleDOI
Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents.
TL;DR: Nine novel analogues of 2 are synthesized, which contain heteroaromatic as well ascycloalkyl B-rings, which solidifies the importance of the 5-hydroxy-6,8,8-trialkyl-4H-chromene-4,7(8H)-dione skeleton (AC-ring system) for the pharmacological activity and establishes the B-ring as less critical for the broader spectrum MDR-selectivity.
Journal ArticleDOI
One-step templated synthesis of chiral organometallic salicyloxazoline complexes.
Mei Luo,Mei Luo,Jing Cheng Zhang,Hao Yin,Cheng Ming Wang,Susan L. Morris-Natschke,Kuo Hsiung Lee,Kuo Hsiung Lee +7 more
TL;DR: The reaction outcome was demonstrated for three-component reactions between metal salts, amino alcohols and 2-hydroxybenzonitrile to afford organometallic complexes in good yields (65–95%).
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Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors
Sheng Biao Wang,Mu Tian Cui,Xiao Feng Wang,Emika Ohkoshi,Masuo Goto,De Xuan Yang,Linna Li,Shoujun Yuan,Susan L. Morris-Natschke,Kuo Hsiung Lee,Kuo Hsiung Lee,Lan Xie +11 more
TL;DR: Molecular modeling elucidated an expected binding mode of 4b with Mer TK and necessary interactions between them, thus supporting the hypothesis that Mer Tk might be a biologic target of this kind of new active compound.
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Cytotoxic Calanquinone A from Calanthe arisanensis and Its First Total Synthesis.
Chia Lin Lee,Kyoko Nakagawa-Goto,Donglei Yu,Yi Nan Liu,Kenneth F. Bastow,Susan L. Morris-Natschke,Fang Rong Chang,Yang Chang Wu,Kuo‐Hsiung Lee +8 more
TL;DR: In this article, the active MeOH extract (225 g) of dry roots of C. arisanensis (5.42 kg) was partitioned between EtOAc and water (1:1, v/v).
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Design, Synthesis and Structure-Activity Relationships of (±)-Isochaihulactone Derivatives.
Yu Zhao,Po Yen Liu,Kan Yen Hsieh,Pei Ling Hsu,Masuo Goto,Susan L. Morris-Natschke,Horng Jyh Harn,Kuo Hsiung Lee,Kuo Hsiung Lee +8 more
TL;DR: The study clearly identified a structural feature that should be retained for good activity and also a moiety that can tolerate various modifications and, thus, is ideal for further changes.