S
Susan L. Morris-Natschke
Researcher at University of North Carolina at Chapel Hill
Publications - 287
Citations - 9762
Susan L. Morris-Natschke is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cytotoxicity & Camptothecin. The author has an hindex of 48, co-authored 284 publications receiving 8331 citations. Previous affiliations of Susan L. Morris-Natschke include China Medical University (Taiwan) & Shandong University.
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Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents
Linyi Wei,Qian Shi,Kenneth F. Bastow,Arnold Brossi,Susan L. Morris-Natschke,Kyoko Nakagawa-Goto,Tian Shung Wu,Shiow Lin Pan,Che-Ming Teng,Kuo Hsiung Lee +9 more
TL;DR: Compound 24b showed modest in vivo antitumor activity against human A549 xenograft in nude mice as well as potent in vitro cytotoxic activity, and thus, is a promising anticancer lead compound.
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The cytotoxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelinol.
Sergio Rosselli,Antonella Maggio,Nicoletta Faraone,Vivienne Spadaro,Susan L. Morris-Natschke,Kenneth F. Bastow,Kuo Hsiung Lee,Maurizio Bruno +7 more
TL;DR: Several natural coumarins isolated from Ferulago campestris and several synthetic ester derivatives of aegelinol were tested against four tumor cell lines and some were shown to be marginally cytotoxic against the A549 lung cancer cell line.
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Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry
Ibrahim D. Bori,Hsin Yi Hung,Keduo Qian,Chin Ho Chen,Susan L. Morris-Natschke,Kuo Hsiung Lee,Kuo Hsiung Lee +6 more
TL;DR: In the present study, a new strategy to link AZT with betulin/betulinic acid (BA) by click chemistry was designed and achieved, and conjugation via a triazole linkage offers a new direction for modification of anti-HIV triterpenes.
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Anti-AIDS Agents 81. Design, Synthesis, and Structure—Activity Relationship Study of Betulinic Acid and Moronic Acid Derivatives as Potent HIV Maturation Inhibitors
TL;DR: This study enabled us to better understand the structure-activity relationships (SAR) of triterpene-derived anti-HIV agents and led to the design and synthesis of compound 12 (EC(50): 0.0006 microM), which displayed slightly better activity than 2 as a HIV-1 maturation inhibitor.
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Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C.
Canio J. Marasco,Claude Piantadosi,Karen L. Meyer,Susan L. Morris-Natschke,Khalid S. Ishaq,George W. Small,Larry W. Daniel +6 more
TL;DR: The goal of this research was to develop ether lipid inhibitors of PKC to augment antineoplastic activity and synthesis and in vitro testing of a series of novel quaternary ammonium derivatives of alkylglycerols showed several analogues with inhibition comparable to that of Et-18-OMe.