S
Susan L. Morris-Natschke
Researcher at University of North Carolina at Chapel Hill
Publications - 287
Citations - 9762
Susan L. Morris-Natschke is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cytotoxicity & Camptothecin. The author has an hindex of 48, co-authored 284 publications receiving 8331 citations. Previous affiliations of Susan L. Morris-Natschke include China Medical University (Taiwan) & Shandong University.
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Journal ArticleDOI
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.
Jin Tatsuzaki,Masahiko Taniguchi,Kenneth F. Bastow,Kyoko Nakagawa-Goto,Susan L. Morris-Natschke,Hideji Itokawa,Kimiye Baba,Kuo Hsiung Lee +7 more
TL;DR: Although GA-DZ conjugates showed potent cytotoxic activity, the individual components (GA and DZ analogs) were inactive suggesting that the GA component is critical for activity.
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Synthesis of sulfur analogues of alkyl lysophospholipid and neoplastic cell growth inhibitory properties.
Susan L. Morris-Natschke,Jefferson R. Surles,Larry W. Daniel,Michael E. Berens,Edward J. Modest,Claude Piantadosi +5 more
TL;DR: Five sulfur-containing phosphate analogues of alkyl lysophospholipid were synthesized and tested for inhibition of neoplastic cell proliferation with two human ovarian carcinoma cell lines in a clonogenic assay and with the HL-60 promyelocytic leukemia cell line.
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Plant-derived Terpenoids and Analogues as Anti-HIV Agents
TL;DR: The plant-derived terpenoids and analogues are reviewed with respect to their anti-HIV activity, structure-activity relationships, and mechanism of action.
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In vitro evaluation of phosphocholine and quaternary ammonium containing lipids as novel anti-HIV agents
Karen L. Meyer,Canino J. Marasco,Susan L. Morris-Natschke,Khalid S. Ishaq,Claude Piantadosi,Louis S. Kucera +5 more
TL;DR: Initial mechanistic studies have indicated that these compounds, unlike AZT, are not reverse transcriptase (RT) inhibitors, but instead appear to inhibit a late step in HIV replication involving virus assembly and infectious virus production.
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Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site
Xiao Feng Wang,Fang Guan,Emika Ohkoshi,Wan-Jun Guo,Lili Wang,Dongqing Zhu,Sheng Biao Wang,Li Ting Wang,Ernest Hamel,Dexuan Yang,Linna Li,Keduo Qian,Susan L. Morris-Natschke,Shoujun Yuan,Kuo Hsiung Lee,Lan Xie +15 more
TL;DR: 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin- 2(1H)-one (5f), the most potent compound, exhibited high in vitro cytotoxic activity, significant potency against tubulin assembly, and substantial inhibition of colchicine binding.