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Susan L. Morris-Natschke

Researcher at University of North Carolina at Chapel Hill

Publications -  287
Citations -  9762

Susan L. Morris-Natschke is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cytotoxicity & Camptothecin. The author has an hindex of 48, co-authored 284 publications receiving 8331 citations. Previous affiliations of Susan L. Morris-Natschke include China Medical University (Taiwan) & Shandong University.

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Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.

Qiang Wang, +10 more
- 09 Sep 2020 - 
TL;DR: Among the synthesized hybrids, two compounds were highly effective against HIV, and compounds 10a and 10b showed more potent or equipotent anti-HIV activity but displayed lower cytotoxicity.
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Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors.

Yu Zhao, +5 more
- 14 Feb 2021 - 
TL;DR: In this paper, a 3D Quantitative Structure-Activity Relationship (SAR) model with high predictability was constructed to facilitate further rational design and development of new potent derivatives.
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Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents

Yizhou Dong, +6 more
- 01 Jan 2011 - 
TL;DR: A novel class of antitumor agents, substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATBO) analogs, evaluated their cytotoxic activity against seven human tumor cell lines from different tissues, and established preliminary structure-activity relationships (SAR).
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Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs.

Shi Qing Xu, +10 more
- 15 Oct 2010 - 
TL;DR: The bioassay results suggest that the spatial orientation of the 2'-methyl group in DCK analogs can have important effects on anti-HIV activity of this compound class.
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Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines.

Hui Ouyang, +6 more
- 20 Jun 2002 - 
TL;DR: Phosphocholines are likely to increase paracellular permeability by modulating the signal transduction pathway initiated by a PLC-catalyzed reaction rather than by physically altering the cell membrane.