S
Susan L. Morris-Natschke
Researcher at University of North Carolina at Chapel Hill
Publications - 287
Citations - 9762
Susan L. Morris-Natschke is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cytotoxicity & Camptothecin. The author has an hindex of 48, co-authored 284 publications receiving 8331 citations. Previous affiliations of Susan L. Morris-Natschke include China Medical University (Taiwan) & Shandong University.
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Journal ArticleDOI
Antitumor agents. 282. 2′-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent.
Yoshihide Usami,Kyoko Nakagawa-Goto,Jingyu Lang,Yoon Kyung Kim,Chin Yu Lai,Masuo Goto,Nobuko Sakurai,Masahiko Taniguchi,Toshiyuki Akiyama,Susan L. Morris-Natschke,Kenneth F. Bastow,Gordon M. Cragg,David J. Newman,Mihoyo Fujitake,Koichi Takeya,Mien Chie Hung,Eva Y.-H. P. Lee,Kuo Hsiung Lee,Kuo Hsiung Lee +18 more
TL;DR: Further investigation using various types of breast and ovarian cancer cell lines suggested that 2'-(R)-O-acetylglaucarubinone (1) does not target the estrogen receptor or progesterone receptor.
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Recent advances in natural anti‐HIV triterpenoids and analogs
Haifeng Wu,Haifeng Wu,Susan L. Morris-Natschke,Xudong Xu,Meihua Yang,Yung Yi Cheng,Yung Yi Cheng,Shi‐Shan Yu,Kuo Hsiung Lee,Kuo Hsiung Lee +9 more
TL;DR: This article includes not only a comprehensive review of the recent anti‐HIV agent development from the perspective of medicinal chemistry, but also discusses structure–activity relationship analyses of the described triterpenoids.
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Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors.
Sheng Biao Wang,Xiao Feng Wang,Bingjie Qin,Emika Ohkoshi,Kan Yen Hsieh,Ernest Hamel,Mu Tian Cui,Dongqing Zhu,Masuo Goto,Susan L. Morris-Natschke,Kuo Hsiung Lee,Kuo Hsiung Lee,Lan Xie +12 more
TL;DR: Compound 4a exhibited high inhibitory potency with low nanomolar GI50 values of 16-20 nM in cellular assays, including excellent activity against the P-glycoprotein overexpressing cell line KBvin, and could be a new potential drug candidate for further development.
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Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.
Ting Zhou,Qian Shi,Chin Ho Chen,Li Huang,Phong Ho,Susan L. Morris-Natschke,Kuo Hsiung Lee,Kuo Hsiung Lee +7 more
TL;DR: Structural-activity relationship information suggested that the extended conjugated system of the pyranoxanthone skeleton facilitates the interaction of the small DCX molecule within the viral binding pocket, consequently leading to enhanced anti-HIV activity and selectivity.
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Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS
Qiang Zhang,Xiaofang Hu,Man man Xin,Hong Bing Liu,Li Juan Sun,Susan L. Morris-Natschke,Yong Chen,Kuo Hsiung Lee,Kuo Hsiung Lee +8 more
TL;DR: The merit of P. alkekengi as an antidiabetic herbal medicine or dietary supplement is supported as measured by ISI and HOMA-IR along with oral glucose tolerance test analysis.