S
Susumu Ohwada
Researcher at Gunma University
Publications - 259
Citations - 4417
Susumu Ohwada is an academic researcher from Gunma University. The author has contributed to research in topics: Cancer & Ischemia. The author has an hindex of 34, co-authored 258 publications receiving 4244 citations. Previous affiliations of Susumu Ohwada include Takeda Pharmaceutical Company.
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Journal ArticleDOI
Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein
Kenichi Tago,Tsutomu Nakamura,Michiru Nishita,Junko Hyodo,Shin-ichi Nagai,Yoji Murata,Shungo Adachi,Susumu Ohwada,Yasuo Morishita,Hiroshi Shibuya,Tetsu Akiyama +10 more
TL;DR: This study shows that a novel β-catenin-interacting protein, termed ICAT (inhibitor of β-Catenin and TCF-4), interferes with the interaction between β- catenin -TCF/LEF-mediated transactivation and antagonizes Wnt signaling.
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Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1
Takayuki Yamada,Koichi Sato,Mayumi Komachi,Enkhzol Malchinkhuu,Masayuki Tobo,Takao Kimura,Atsushi Kuwabara,Yasuhiro Yanagita,Toshiro Ikeya,Yoshifumi Tanahashi,Tetsushi Ogawa,Susumu Ohwada,Yasuo Morishita,Hideo Ohta,Doon-Soon Im,Koichi Tamoto,Hideaki Tomura,Fumikazu Okajima +17 more
TL;DR: It is suggested that LPA is a critical component of ascites for the motility of pancreatic cancer cells and LPA1 receptors may mediate this activity.
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NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells
Noritaka Yamaguchi,Tetsunari Oyama,Emi Ito,Hitoshi Satoh,Sakura Azuma,Mitsuhiro Hayashi,Ken Shimizu,Reiko Honma,Yuka Yanagisawa,Akira Nishikawa,Mika Kawamura,Jun-ichi Imai,Jun-ichi Imai,Susumu Ohwada,Kuniaki Tatsuta,Jun-ichiro Inoue,Kentaro Semba,Shinya Watanabe,Shinya Watanabe +18 more
TL;DR: Findings indicate that NOTCH3-mediated signaling rather than NOTCH1- mediated signaling plays an important role in the proliferation of ErbB2-negative breast tumor cells and that targeted suppression of this signaling pathway may be a promising strategy for the treatment of Er bBB 2- negative breast cancers.
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Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-β Signaling, as a Target of the β-Catenin Pathway in Colorectal Tumor Cells
Takashi Sekiya,Shungo Adachi,Kazuyoshi Kohu,Tatsuya Yamada,Osamu Higuchi,Yoichi Furukawa,Yusuke Nakamura,Tsutomu Nakamura,Kousuke Tashiro,Satoru Kuhara,Susumu Ohwada,Tetsu Akiyama +11 more
TL;DR: It is suggested that β-catenin interferes with transforming growth factor-β-mediated growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.
Journal ArticleDOI
Amplification of c-myc in hepatocellular carcinoma: correlation with clinicopathologic features, proliferative activity and p53 overexpression.
TL;DR: C-myc amplification is an indicator of malignant potential and poor prognosis in hepatocellular carcinoma and p53 alteration may be coparticipating events in the progression of these tumors.