Journal ArticleDOI
Amplification of c-myc in hepatocellular carcinoma: correlation with clinicopathologic features, proliferative activity and p53 overexpression.
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TLDR
C-myc amplification is an indicator of malignant potential and poor prognosis in hepatocellular carcinoma and p53 alteration may be coparticipating events in the progression of these tumors.Abstract:
Expression of the proto-oncogene c- myc has been implicated in liver regeneration and hepatocarcinogenesis. The biologic significance of c- myc gene amplification iread more
Citations
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MYC Activation Is a Hallmark of Cancer Initiation and Maintenance
TL;DR: Tumors appear to be "addicted" to MYC because of both tumor cell-intrinsic, cell-autonomous and host-dependent, immune cell-dependent mechanisms.
Journal ArticleDOI
The Myc oncoprotein as a therapeutic target for human cancer.
Marina Vita,Marie Henriksson +1 more
TL;DR: An overview of Myc activation in human tumors is given and current strategies aimed at targeting Myc for cancer treatment are discussed.
Journal ArticleDOI
Acetate dependence of tumors.
Sarah A. Comerford,Zhiguang Huang,Xinlin Du,Yun Wang,Ling Cai,Agnieszka K. Witkiewicz,Holly Walters,Mohammed N. Tantawy,Allie Fu,H. Charles Manning,Jay D. Horton,Robert E. Hammer,Steven L. McKnight,Benjamin P. Tu +13 more
TL;DR: It is shown that the nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key source of acetyl -CoA for tumors by capturing acetate as a carbon source.
Journal ArticleDOI
Hepatocellular carcinoma--cause, treatment and metastasis.
TL;DR: Biotherapy, such as cytokines, differentiation inducers, anti-angiogenic agents, gene therapy and tumor vaccine will probably play a role, particularly in the prevention of tumor recurrence, and HCC invasiveness is currently the major target of study.
Journal ArticleDOI
The prognostic molecular markers in hepatocellular carcinoma.
Lun-Xiu Qin,Zhao-You Tang +1 more
TL;DR: The prognosis of hepatocellular carcinoma still remains dismal, although many advances in its clinical study have been made and more and more new prognostic markers with high sensitivity and specificity will be found and used in clinical assays.
References
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Journal ArticleDOI
Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.
Journal ArticleDOI
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Gianluca Gaidano,P. Ballerini,Jerry Z. Gong,Giorgio Inghirami,Antonino Neri,Elizabeth W. Newcomb,Ian T. Magrath,Daniel M. Knowles,Riccardo Dalla-Favera +8 more
TL;DR: It is suggested that p53 may play a role in tumor progression in B-cell chronic lymphocytic leukemia and the presence of both p53 loss/inactivation and c-myc oncogene activation may be important in the pathogenesis of Burkitt lymphoma and its leukemic form L3-type B- cell acute lymphoblastic leukemia.
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An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53.
TL;DR: In this article, the authors used bacterial expression systems to produce fragments of human p53 and then isolated and characterized new monoclonal antibodies to p53, which are suitable for the measurement of p53 in ELISA, immunoblotting and immunoprecipitation analyses.
Journal ArticleDOI
Nucleolar organizer regions in lymphomas
John Crocker,Paramjit Nar +1 more
TL;DR: Using a silver staining technique, nucleolar organizer region‐associated proteins (Ag‐NORs) have been studied in paraffin sections of 90 non‐Hodgkin's lymphomas, five palatine tonsils and five ‘reactive’ lymph nodes.
Journal Article
New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope.
TL;DR: It is demonstrated that it is possible to use bacterially expressed parts of the Ki-67 antigen as immunogen to elicit antibodies that react with the native antigen, and the new antibodies may become powerful tools for routine histopathology and for further functional characterization of the KS antigen.