S
Sydney Croul
Publications - 1
Citations - 610
Sydney Croul is an academic researcher. The author has contributed to research in topics: Smoothened & PTCH1. The author has an hindex of 1, co-authored 1 publications receiving 511 citations.
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Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
Marcel Kool,David T.W. Jones,Natalie Jäger,Paul A. Northcott,Trevor J. Pugh,Volker Hovestadt,Rosario M. Piro,L. Adriana Esparza,Shirley L. Markant,Marc Remke,Till Milde,Franck Bourdeaut,Marina Ryzhova,Dominik Sturm,Elke Pfaff,Sebastian Stark,Sonja Hutter,Huriye Seker-Cin,Pascal Johann,Sebastian Bender,Christin Schmidt,Tobias Rausch,David Shih,Jüri Reimand,Laura Sieber,Andrea Wittmann,Linda Linke,Hendrik Witt,Hendrik Witt,Ursula D. Weber,Marc Zapatka,Rainer König,Rainer König,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Guillaume Bergthold,Guillaume Bergthold,Guillaume Bergthold,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Sabine Schmidt,Stephan Wolf,Chris Lawerenz,Cynthia C. Bartholomae,Christof von Kalle,Andreas Unterberg,Christel Herold-Mende,Silvia Hofer,Andreas E. Kulozik,Andreas von Deimling,Andreas von Deimling,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Martin Hasselblatt,John R. Crawford,John R. Crawford,Gerald A. Grant,Nada Jabado,Arie Perry,Cynthia Cowdrey,Sydney Croul,Gelareh Zadeh,Jan O. Korbel,François Doz,François Doz,Olivier Delattre,Gary D. Bader,Martin G. McCabe,V. Peter Collins,Mark W. Kieran,Yoon Jae Cho,Scott L. Pomeroy,Olaf Witt,Benedikt Brors,Michael D. Taylor,Ulrich Schüller,Andrey Korshunov,Andrey Korshunov,Roland Eils,Robert J. Wechsler-Reya,Peter Lichter,Stefan M. Pfister,Stefan M. Pfister +86 more
TL;DR: Functional assays in different SHH-MB xenograft models demonstrated that SHh-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant.