C
Christel Herold-Mende
Researcher at German Cancer Research Center
Publications - 7
Citations - 866
Christel Herold-Mende is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Smoothened & Radiogenomics. The author has an hindex of 3, co-authored 7 publications receiving 700 citations. Previous affiliations of Christel Herold-Mende include University Hospital Heidelberg.
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Journal ArticleDOI
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
Marcel Kool,David T.W. Jones,Natalie Jäger,Paul A. Northcott,Trevor J. Pugh,Volker Hovestadt,Rosario M. Piro,L. Adriana Esparza,Shirley L. Markant,Marc Remke,Till Milde,Franck Bourdeaut,Marina Ryzhova,Dominik Sturm,Elke Pfaff,Sebastian Stark,Sonja Hutter,Huriye Seker-Cin,Pascal Johann,Sebastian Bender,Christin Schmidt,Tobias Rausch,David Shih,Jüri Reimand,Laura Sieber,Andrea Wittmann,Linda Linke,Hendrik Witt,Hendrik Witt,Ursula D. Weber,Marc Zapatka,Rainer König,Rainer König,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Guillaume Bergthold,Guillaume Bergthold,Guillaume Bergthold,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Sabine Schmidt,Stephan Wolf,Chris Lawerenz,Cynthia C. Bartholomae,Christof von Kalle,Andreas Unterberg,Christel Herold-Mende,Silvia Hofer,Andreas E. Kulozik,Andreas von Deimling,Andreas von Deimling,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Martin Hasselblatt,John R. Crawford,John R. Crawford,Gerald A. Grant,Nada Jabado,Arie Perry,Cynthia Cowdrey,Sydney Croul,Gelareh Zadeh,Jan O. Korbel,François Doz,François Doz,Olivier Delattre,Gary D. Bader,Martin G. McCabe,V. Peter Collins,Mark W. Kieran,Yoon Jae Cho,Scott L. Pomeroy,Olaf Witt,Benedikt Brors,Michael D. Taylor,Ulrich Schüller,Andrey Korshunov,Andrey Korshunov,Roland Eils,Robert J. Wechsler-Reya,Peter Lichter,Stefan M. Pfister,Stefan M. Pfister +86 more
TL;DR: Functional assays in different SHH-MB xenograft models demonstrated that SHh-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant.
Journal ArticleDOI
Radiogenomics of Glioblastoma: Machine Learning–based Classification of Molecular Characteristics by Using Multiparametric and Multiregional MR Imaging Features
Philipp Kickingereder,David Bonekamp,Martha Nowosielski,Annekathrin Kratz,Martin Sill,Sina Burth,Antje Wick,Oliver Eidel,Heinz Peter Schlemmer,Alexander Radbruch,Jürgen Debus,Christel Herold-Mende,Andreas Unterberg,David T.W. Jones,Stefan M. Pfister,Wolfgang Wick,Andreas von Deimling,Martin Bendszus,David Capper +18 more
TL;DR: In this paper, the authors evaluated the association of multiparametric and multiregional magnetic resonance (MR) imaging features with key molecular characteristics in patients with newly diagnosed glioblastoma.
Journal ArticleDOI
Microscopic brain invasion in meningiomas previously classified as WHO grade I is not associated with patient outcome.
Annamaria Biczok,Annamaria Biczok,Christine Jungk,Christine Jungk,Rupert Egensperger,Rupert Egensperger,Andreas von Deimling,Andreas von Deimling,Bogdana Suchorska,Bogdana Suchorska,Joerg C. Tonn,Joerg C. Tonn,Christel Herold-Mende,Christel Herold-Mende,Christian Schichor,Christian Schichor +15 more
TL;DR: In this bi-institutional series, brain invasion was frequent among meningiomas WHO grade I when brain/meningioma interface was available for histology (16.5%) but did not impact early recurrence.
Journal ArticleDOI
Glioblastoma evolution pattern under surgery and radio(chemo)therapy (RCHT) to identify novel methylome based glioma subtypes.
Maximilian Knoll,Juergen Debus,Jennifer Furkel,Rolf Warta,Nina Bougatf,Carmen Rapp,Benedikt Brors,Wolfgang Wick,Andreas Unterberg,Christel Herold-Mende,Amir Abdollahi +10 more
TL;DR: Identification of isocitrate dehydrogenase mutations and glioma CpG island methylator phenotype (G-CIMP) as well as methylation of O6-methylguanine DNA methyltransferase (MGM...
Journal ArticleDOI
Discovery of a reliable and robust methylome classifier of HPV driven head and neck cancer with favorable response to chemoradiation: A multicenter study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).
Bouchra Tawk,Juergen Debus,Christian Schwager,Annett Linge,Ute Ganswindt,Inge Tinhofer,Volker Budach,Martin Stuschke,Panagiotis Balermpas,F. Rödel,Anca L. Grosu,Daniel Zips,Stephanie E. Combs,Mechthild Krause,Wilko Weichert,Michael Baumann,Claus Belka,Gerhard Dyckhoff,Christel Herold-Mende,Amir Abdollahi +19 more
TL;DR: Human Papilloma Virus-driven head and neck cancer (HNSCC) is associated with good prognosis and the prognostic value of HPV-DNA and p16 IHC was recently reported.