L
Linda Linke
Researcher at German Cancer Research Center
Publications - 3
Citations - 1146
Linda Linke is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Downregulation and upregulation & Smoothened. The author has an hindex of 3, co-authored 3 publications receiving 945 citations.
Papers
More filters
Journal ArticleDOI
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
Marcel Kool,David T.W. Jones,Natalie Jäger,Paul A. Northcott,Trevor J. Pugh,Volker Hovestadt,Rosario M. Piro,L. Adriana Esparza,Shirley L. Markant,Marc Remke,Till Milde,Franck Bourdeaut,Marina Ryzhova,Dominik Sturm,Elke Pfaff,Sebastian Stark,Sonja Hutter,Huriye Seker-Cin,Pascal Johann,Sebastian Bender,Christin Schmidt,Tobias Rausch,David Shih,Jüri Reimand,Laura Sieber,Andrea Wittmann,Linda Linke,Hendrik Witt,Hendrik Witt,Ursula D. Weber,Marc Zapatka,Rainer König,Rainer König,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Guillaume Bergthold,Guillaume Bergthold,Guillaume Bergthold,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Sabine Schmidt,Stephan Wolf,Chris Lawerenz,Cynthia C. Bartholomae,Christof von Kalle,Andreas Unterberg,Christel Herold-Mende,Silvia Hofer,Andreas E. Kulozik,Andreas von Deimling,Andreas von Deimling,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Martin Hasselblatt,John R. Crawford,John R. Crawford,Gerald A. Grant,Nada Jabado,Arie Perry,Cynthia Cowdrey,Sydney Croul,Gelareh Zadeh,Jan O. Korbel,François Doz,François Doz,Olivier Delattre,Gary D. Bader,Martin G. McCabe,V. Peter Collins,Mark W. Kieran,Yoon Jae Cho,Scott L. Pomeroy,Olaf Witt,Benedikt Brors,Michael D. Taylor,Ulrich Schüller,Andrey Korshunov,Andrey Korshunov,Roland Eils,Robert J. Wechsler-Reya,Peter Lichter,Stefan M. Pfister,Stefan M. Pfister +86 more
TL;DR: Functional assays in different SHH-MB xenograft models demonstrated that SHh-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant.
Journal ArticleDOI
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Paul A. Northcott,Catherine A. Lee,Catherine A. Lee,Thomas Zichner,Adrian M. Stütz,Serap Erkek,Daisuke Kawauchi,David Shih,Volker Hovestadt,Marc Zapatka,Dominik Sturm,David T.W. Jones,Marcel Kool,Marc Remke,Florence M.G. Cavalli,Scott Zuyderduyn,Gary D. Bader,Scott R. VandenBerg,Lourdes Adriana Esparza,Marina Ryzhova,Wei Wang,Andrea Wittmann,Sebastian Stark,Laura Sieber,Huriye Seker-Cin,Linda Linke,Fabian Kratochwil,Natalie Jäger,Ivo Buchhalter,Charles D. Imbusch,Gideon Zipprich,Benjamin Raeder,Sabine Schmidt,Nicolle Diessl,Stephan Wolf,Stefan Wiemann,Benedikt Brors,Chris Lawerenz,Jürgen Eils,Hans-Jörg Warnatz,Thomas Risch,Marie-Laure Yaspo,Ursula D. Weber,Cynthia C. Bartholomae,Christof von Kalle,Eszter Turányi,Peter Hauser,Emma Sandén,Anna Darabi,Peter Siesjö,Jaroslav Sterba,Karel Zitterbart,David Sumerauer,Peter van Sluis,Rogier Versteeg,Richard Volckmann,Jan Koster,Martin U. Schuhmann,Martin Ebinger,H. Leighton Grimes,Giles W. Robinson,Amar Gajjar,Martin Mynarek,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Andreas E. Kulozik,Andreas von Deimling,Olaf Witt,Roland Eils,Richard J. Gilbertson,Andrey Korshunov,Michael D. Taylor,Peter Lichter,Jan O. Korbel,Robert J. Wechsler-Reya,Stefan M. Pfister +79 more
TL;DR: GFI1 and GFI1B are identified as prominent medulloblastoma oncogenes and ‘enhancer hijacking’ is implicate as an efficient mechanism driving oncogene activation in a childhood cancer.
Journal ArticleDOI
The Tolerogenic Function of Annexins on Apoptotic Cells Is Mediated by the Annexin Core Domain
Björn Linke,Lucie Abeler-Dörner,Veronika Jahndel,Alexandra Kurz,Andrea Mahr,Sandra Pfrang,Linda Linke,Peter H. Krammer,Heiko Weyd +8 more
TL;DR: It is shown that the annexin (Anx) family members AnxA5 and Anxa13 translocate to the surface of ACs to function as redundant tolerogenic signals in vitro and in vivo and suggest that several Anxs contribute to AC-induced suppression of dendritic cell activation.