H
Huriye Seker-Cin
Researcher at German Cancer Research Center
Publications - 11
Citations - 3230
Huriye Seker-Cin is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Medulloblastoma & DNA methylation. The author has an hindex of 9, co-authored 9 publications receiving 2667 citations.
Papers
More filters
Journal ArticleDOI
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
David T.W. Jones,Barbara Hutter,Natalie Jäger,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Hans-Jörg Warnatz,Thomas Zichner,Sally R. Lambert,Marina Ryzhova,Dong Anh Khuong Quang,Adam M. Fontebasso,Adrian M. Stütz,Sonja Hutter,Marc Zuckermann,Dominik Sturm,Jan Gronych,Bärbel Lasitschka,Sabine Schmidt,Huriye Seker-Cin,Hendrik Witt,Hendrik Witt,Marc Sultan,Meryem Ralser,Paul A. Northcott,Volker Hovestadt,Sebastian Bender,Elke Pfaff,Sebastian Stark,Damien Faury,Jeremy Schwartzentruber,Jacek Majewski,Ursula D. Weber,Marc Zapatka,Benjamin Raeder,Matthias Schlesner,Catherine L. Worth,Cynthia C. Bartholomae,Christof von Kalle,Charles D. Imbusch,S. Radomski,S. Radomski,Chris Lawerenz,Peter van Sluis,Jan Koster,Richard Volckmann,Rogier Versteeg,Hans Lehrach,Camelia M. Monoranu,Beate Winkler,Andreas Unterberg,Christel Herold-Mende,Till Milde,Till Milde,Andreas E. Kulozik,Martin Ebinger,Martin U. Schuhmann,Yoon Jae Cho,Scott L. Pomeroy,Scott L. Pomeroy,Andreas von Deimling,Andreas von Deimling,Olaf Witt,Olaf Witt,Michael D. Taylor,Stephan Wolf,Matthias A. Karajannis,Charles G. Eberhart,Wolfram Scheurlen,Martin Hasselblatt,Keith L. Ligon,Mark W. Kieran,Jan O. Korbel,Marie-Laure Yaspo,Benedikt Brors,Jörg Felsberg,Guido Reifenberger,V. Peter Collins,Nada Jabado,Nada Jabado,Roland Eils,Roland Eils,Peter Lichter +82 more
TL;DR: Recurrent activating mutations in FGFR1 and PTPN11 and new NTRK2 fusion genes in non-cerebellar tumors and new BRAF-activating changes were observed, indicating that pilocytic astrocytoma is predominantly a single-pathway disease.
Journal ArticleDOI
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
Marcel Kool,David T.W. Jones,Natalie Jäger,Paul A. Northcott,Trevor J. Pugh,Volker Hovestadt,Rosario M. Piro,L. Adriana Esparza,Shirley L. Markant,Marc Remke,Till Milde,Franck Bourdeaut,Marina Ryzhova,Dominik Sturm,Elke Pfaff,Sebastian Stark,Sonja Hutter,Huriye Seker-Cin,Pascal Johann,Sebastian Bender,Christin Schmidt,Tobias Rausch,David Shih,Jüri Reimand,Laura Sieber,Andrea Wittmann,Linda Linke,Hendrik Witt,Hendrik Witt,Ursula D. Weber,Marc Zapatka,Rainer König,Rainer König,Rameen Beroukhim,Rameen Beroukhim,Rameen Beroukhim,Guillaume Bergthold,Guillaume Bergthold,Guillaume Bergthold,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Sabine Schmidt,Stephan Wolf,Chris Lawerenz,Cynthia C. Bartholomae,Christof von Kalle,Andreas Unterberg,Christel Herold-Mende,Silvia Hofer,Andreas E. Kulozik,Andreas von Deimling,Andreas von Deimling,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Martin Hasselblatt,John R. Crawford,John R. Crawford,Gerald A. Grant,Nada Jabado,Arie Perry,Cynthia Cowdrey,Sydney Croul,Gelareh Zadeh,Jan O. Korbel,François Doz,François Doz,Olivier Delattre,Gary D. Bader,Martin G. McCabe,V. Peter Collins,Mark W. Kieran,Yoon Jae Cho,Scott L. Pomeroy,Olaf Witt,Benedikt Brors,Michael D. Taylor,Ulrich Schüller,Andrey Korshunov,Andrey Korshunov,Roland Eils,Robert J. Wechsler-Reya,Peter Lichter,Stefan M. Pfister,Stefan M. Pfister +86 more
TL;DR: Functional assays in different SHH-MB xenograft models demonstrated that SHh-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant.
Journal ArticleDOI
Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
Sebastian Bender,Sebastian Bender,Yujie Tang,Anders Lindroth,Volker Hovestadt,David T.W. Jones,Marcel Kool,Marc Zapatka,Paul A. Northcott,Dominik Sturm,Wei Wang,Bernhard Radlwimmer,Jonas W. Højfeldt,Nathalene Truffaux,David Castel,Simone Schubert,Marina Ryzhova,Huriye Seker-Cin,Jan Gronych,Pascal-David Johann,Pascal-David Johann,Sebastian Stark,Sebastian Stark,Jochen Meyer,Jochen Meyer,Till Milde,Till Milde,Martin U. Schuhmann,Martin Ebinger,Camelia M. Monoranu,Anitha Ponnuswami,S. Chen,Chris Jones,Olaf Witt,Olaf Witt,V. Peter Collins,Andreas von Deimling,Andreas von Deimling,Nada Jabado,Stéphanie Puget,Jacques Grill,Kristian Helin,Andrey Korshunov,Andrey Korshunov,Peter Lichter,Michelle Monje,Christoph Plass,Yoon Jae Cho,Stefan M. Pfister,Stefan M. Pfister +49 more
TL;DR: It is shown that reduced H3K27me3 levels and DNA hypomethylation act in concert to activate gene expression in K27M mutant pHGGs, and it is demonstrated that this is caused by aberrant recruitment of the PRC2 complex to K 27M mutant H3.3.
Journal ArticleDOI
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Paul A. Northcott,Catherine A. Lee,Catherine A. Lee,Thomas Zichner,Adrian M. Stütz,Serap Erkek,Daisuke Kawauchi,David Shih,Volker Hovestadt,Marc Zapatka,Dominik Sturm,David T.W. Jones,Marcel Kool,Marc Remke,Florence M.G. Cavalli,Scott Zuyderduyn,Gary D. Bader,Scott R. VandenBerg,Lourdes Adriana Esparza,Marina Ryzhova,Wei Wang,Andrea Wittmann,Sebastian Stark,Laura Sieber,Huriye Seker-Cin,Linda Linke,Fabian Kratochwil,Natalie Jäger,Ivo Buchhalter,Charles D. Imbusch,Gideon Zipprich,Benjamin Raeder,Sabine Schmidt,Nicolle Diessl,Stephan Wolf,Stefan Wiemann,Benedikt Brors,Chris Lawerenz,Jürgen Eils,Hans-Jörg Warnatz,Thomas Risch,Marie-Laure Yaspo,Ursula D. Weber,Cynthia C. Bartholomae,Christof von Kalle,Eszter Turányi,Peter Hauser,Emma Sandén,Anna Darabi,Peter Siesjö,Jaroslav Sterba,Karel Zitterbart,David Sumerauer,Peter van Sluis,Rogier Versteeg,Richard Volckmann,Jan Koster,Martin U. Schuhmann,Martin Ebinger,H. Leighton Grimes,Giles W. Robinson,Amar Gajjar,Martin Mynarek,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Wolfram Scheurlen,Jörg Felsberg,Guido Reifenberger,Andreas E. Kulozik,Andreas von Deimling,Olaf Witt,Roland Eils,Richard J. Gilbertson,Andrey Korshunov,Michael D. Taylor,Peter Lichter,Jan O. Korbel,Robert J. Wechsler-Reya,Stefan M. Pfister +79 more
TL;DR: GFI1 and GFI1B are identified as prominent medulloblastoma oncogenes and ‘enhancer hijacking’ is implicate as an efficient mechanism driving oncogene activation in a childhood cancer.
Journal ArticleDOI
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Stephen C. Mack,Hendrik Witt,Rosario M. Piro,L. Gu,Scott Zuyderduyn,Adrian M. Stütz,Xin Wang,Marco Gallo,Livia Garzia,Kory Zayne,Xiaoyang Zhang,Vijay Ramaswamy,Natalie Jäger,David T.W. Jones,Martin Sill,T. J. Pugh,Marina Ryzhova,Khalida Wani,David Shih,Renee Head,Marc Remke,Swneke D. Bailey,Thomas Zichner,Claudia C. Faria,Mark Barszczyk,Sebastian Stark,Huriye Seker-Cin,Sonja Hutter,Pascal Johann,Sebastian Bender,Volker Hovestadt,Theophilos Tzaridis,Adrian M. Dubuc,Paul A. Northcott,John Peacock,Kelsey C. Bertrand,Sameer Agnihotri,Florence M.G. Cavalli,Ian D. Clarke,K. Nethery-Brokx,Caretha L. Creasy,Sharad K. Verma,Jan Koster,Xiaochong Wu,Yuan Yao,Till Milde,Patrick Sin-Chan,Jennifer Zuccaro,Loretta Lau,Sergio L. Pereira,Pedro Castelo-Branco,Martin Hirst,Marco A. Marra,Stephen S. Roberts,Daniel W. Fults,Luca Massimi,Yoon Jae Cho,T. Van Meter,Wiesława Grajkowska,Boleslaw Lach,Andreas E. Kulozik,A. von Deimling,Olaf Witt,Stephen W. Scherer,Xing Fan,Karin M. Muraszko,Marcel Kool,Scott L. Pomeroy,Nalin Gupta,Joanna J. Phillips,Annie Huang,Uri Tabori,Cynthia Hawkins,David Malkin,Paul Kongkham,William A. Weiss,Nada Jabado,James T. Rutka,Eric Bouffet,Jan O. Korbel,Mathieu Lupien,Kenneth Aldape,Gary D. Bader,Roland Eils,Peter Lichter,Peter B. Dirks,Stefan M. Pfister,Andrey Korshunov,Michael D. Taylor +88 more
TL;DR: It is concluded that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.