R
Raimund Fromme
Researcher at Arizona State University
Publications - 81
Citations - 8721
Raimund Fromme is an academic researcher from Arizona State University. The author has contributed to research in topics: Femtosecond & Time resolved crystallography. The author has an hindex of 33, co-authored 72 publications receiving 7744 citations. Previous affiliations of Raimund Fromme include Technical University of Berlin & Biodesign Institute.
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Journal ArticleDOI
Femtosecond X-ray protein nanocrystallography
Henry N. Chapman,Petra Fromme,Anton Barty,Thomas A. White,Richard A. Kirian,Andrew Aquila,Mark S. Hunter,Joachim Schulz,Daniel P. DePonte,Uwe Weierstall,R. Bruce Doak,Filipe R. N. C. Maia,Andrew V. Martin,Ilme Schlichting,Lukas Lomb,Nicola Coppola,Robert L. Shoeman,Sascha W. Epp,Robert Hartmann,Daniel Rolles,Artem Rudenko,Lutz Foucar,Nils Kimmel,Georg Weidenspointner,Peter Holl,Mengning Liang,Miriam Barthelmess,Carl Caleman,Sébastien Boutet,Michael J. Bogan,Jacek Krzywinski,Christoph Bostedt,Saša Bajt,Lars Gumprecht,Benedikt Rudek,Benjamin Erk,Carlo Schmidt,André Hömke,Christian Reich,Daniel Pietschner,Lothar Strüder,Günter Hauser,H. Gorke,Joachim Ullrich,Sven Herrmann,Gerhard Schaller,Florian Schopper,Heike Soltau,Kai-Uwe Kühnel,Marc Messerschmidt,John D. Bozek,Stefan P. Hau-Riege,Matthias Frank,Christina Y. Hampton,Raymond G. Sierra,Dmitri Starodub,Garth J. Williams,Janos Hajdu,Nicusor Timneanu,M. Marvin Seibert,M. Marvin Seibert,Jakob Andreasson,Andrea Rocker,Olof Jönsson,Martin Svenda,Stephan Stern,Karol Nass,Robert Andritschke,Claus Dieter Schröter,Faton Krasniqi,Mario Bott,Kevin Schmidt,Xiaoyu Wang,Ingo Grotjohann,James M. Holton,Thomas R. M. Barends,Richard Neutze,Stefano Marchesini,Raimund Fromme,Sebastian Schorb,Daniela Rupp,M. Adolph,Tais Gorkhover,Inger Andersson,Helmut Hirsemann,Guillaume Potdevin,Heinz Graafsma,Björn Nilsson,John C. H. Spence +88 more
TL;DR: This work offers a new approach to structure determination of macromolecules that do not yield crystals of sufficient size for studies using conventional radiation sources or are particularly sensitive to radiation damage, by using pulses briefer than the timescale of most damage processes.
Journal ArticleDOI
High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography
Sébastien Boutet,Lukas Lomb,Garth J. Williams,Thomas R. M. Barends,Andrew Aquila,R. Bruce Doak,Uwe Weierstall,Daniel P. DePonte,Jan Steinbrener,Robert L. Shoeman,Marc Messerschmidt,Anton Barty,Thomas A. White,Stephan Kassemeyer,Richard A. Kirian,M. Marvin Seibert,Paul A. Montanez,C.J. Kenney,Ryan Herbst,P. Hart,J. Pines,Gunther Haller,Sol M. Gruner,Hugh T. Philipp,Mark W. Tate,Marianne Hromalik,Lucas J. Koerner,Niels van Bakel,John Morse,W. Ghonsalves,David Arnlund,Michael J. Bogan,Carl Caleman,Raimund Fromme,Christina Y. Hampton,Mark S. Hunter,Linda C. Johansson,Gergely Katona,Christopher Kupitz,Mengning Liang,Andrew V. Martin,Karol Nass,Lars Redecke,Lars Redecke,Francesco Stellato,Nicusor Timneanu,Dingjie Wang,Nadia A. Zatsepin,Donald W. Schafer,James Defever,Richard Neutze,Petra Fromme,John C. H. Spence,Henry N. Chapman,Ilme Schlichting +54 more
TL;DR: Serial femtosecond crystallography (SFX) is applied using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals of the well-characterized model protein lysozyme, demonstrating the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.
Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
Uwe Weierstall,Daniel James,Chong Wang,Thomas A. White,Dingjie Wang,Wei Liu,John C. H. Spence,R. Bruce Doak,Garrett Nelson,Petra Fromme,Raimund Fromme,Ingo Grotjohann,Christopher Kupitz,Nadia A. Zatsepin,Haiguang Liu,Shibom Basu,Daniel Wacker,Gye Won Han,Vsevolod Katritch,Sébastien Boutet,Marc Messerschmidt,Garth J. Williams,Jason E. Koglin,M. Marvin Seibert,M. Marvin Seibert,Markus Klinker,Cornelius Gati,Robert L. Shoeman,Anton Barty,Henry N. Chapman,Richard A. Kirian,Kenneth R. Beyerlein,Raymond C. Stevens,Dianfan Li,Syed T. A. Shah,Nicole Howe,Martin Caffrey,Vadim Cherezov +37 more
TL;DR: This work presents a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography.
Journal ArticleDOI
Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser
Lars Redecke,Lars Redecke,Karol Nass,Daniel P. DePonte,Thomas A. White,Dirk Rehders,Anton Barty,Francesco Stellato,Mengning Liang,Thomas R. M. Barends,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,M. Marvin Seibert,Andrew Aquila,David Arnlund,Saša Bajt,Torsten Barth,Michael J. Bogan,Carl Caleman,Tzu-Chiao Chao,R. Bruce Doak,Holger Fleckenstein,Matthias Frank,Raimund Fromme,Lorenzo Galli,Ingo Grotjohann,Mark S. Hunter,Linda C. Johansson,Stephan Kassemeyer,Gergely Katona,Richard A. Kirian,Rudolf Koopmann,Chris Kupitz,Lukas Lomb,Andrew V. Martin,Stefan Mogk,Richard Neutze,Robert L. Shoeman,Jan Steinbrener,Nicusor Timneanu,Dingjie Wang,Uwe Weierstall,Nadia A. Zatsepin,John C. H. Spence,Petra Fromme,Ilme Schlichting,Michael Duszenko,Christian Betzel,Henry N. Chapman +49 more
TL;DR: The structure reveals the mechanism of native TbCatB inhibition and demonstrates that new biomolecular information can be obtained by the “diffraction-before-destruction” approach of x-ray free-electron lasers from hundreds of thousands of individual microcrystals.