S
Shibom Basu
Researcher at Paul Scherrer Institute
Publications - 52
Citations - 4398
Shibom Basu is an academic researcher from Paul Scherrer Institute. The author has contributed to research in topics: Femtosecond & Resolution (electron density). The author has an hindex of 22, co-authored 50 publications receiving 3760 citations. Previous affiliations of Shibom Basu include Arizona State University & European Bioinformatics Institute.
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Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
Journal ArticleDOI
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
Uwe Weierstall,Daniel James,Chong Wang,Thomas A. White,Dingjie Wang,Wei Liu,John C. H. Spence,R. Bruce Doak,Garrett Nelson,Petra Fromme,Raimund Fromme,Ingo Grotjohann,Christopher Kupitz,Nadia A. Zatsepin,Haiguang Liu,Shibom Basu,Daniel Wacker,Gye Won Han,Vsevolod Katritch,Sébastien Boutet,Marc Messerschmidt,Garth J. Williams,Jason E. Koglin,M. Marvin Seibert,M. Marvin Seibert,Markus Klinker,Cornelius Gati,Robert L. Shoeman,Anton Barty,Henry N. Chapman,Richard A. Kirian,Kenneth R. Beyerlein,Raymond C. Stevens,Dianfan Li,Syed T. A. Shah,Nicole Howe,Martin Caffrey,Vadim Cherezov +37 more
TL;DR: This work presents a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography.
Journal ArticleDOI
Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.
Christopher Kupitz,Shibom Basu,Ingo Grotjohann,Raimund Fromme,Nadia A. Zatsepin,Kimberly N. Rendek,Mark S. Hunter,Mark S. Hunter,Robert L. Shoeman,Thomas A. White,Dingjie Wang,Daniel James,Jay-How Yang,Danielle E. Cobb,Brenda Reeder,Raymond G. Sierra,Haiguang Liu,Anton Barty,Andrew Aquila,Daniel P. DePonte,Richard A. Kirian,Sadia Bari,Jesse J. Bergkamp,Kenneth R. Beyerlein,Michael J. Bogan,Carl Caleman,Tzu-Chiao Chao,Tzu-Chiao Chao,Chelsie E. Conrad,Katherine M. Davis,Holger Fleckenstein,Lorenzo Galli,Stefan P. Hau-Riege,Stephan Kassemeyer,Hartawan Laksmono,Mengning Liang,Lukas Lomb,Stefano Marchesini,Andrew V. Martin,Marc Messerschmidt,Despina Milathianaki,Karol Nass,Alexandra Ros,Shatabdi Roy-Chowdhury,Kevin Schmidt,M. Marvin Seibert,M. Marvin Seibert,Jan Steinbrener,Francesco Stellato,Lifen Yan,Chun Hong Yoon,Thomas A. Moore,Ana L. Moore,Yulia Pushkar,Garth J. Williams,Sébastien Boutet,R. Bruce Doak,Uwe Weierstall,Matthias Frank,Henry N. Chapman,John C. H. Spence,Petra Fromme +61 more
TL;DR: Time resolved experiments on PSII nano/microcrystals from Thermosynechococcus elongatus performed with the recently developed technique of serial femtosecond crystallography provide evidence that PSII undergoes significant conformational changes at the electron acceptor side and at the Mn4CaO5 core of the OEC.
Journal ArticleDOI
Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein
Jason Tenboer,Shibom Basu,Nadia A. Zatsepin,Kanupriya Pande,Despina Milathianaki,Matthias Frank,Mark S. Hunter,Sébastien Boutet,Garth J. Williams,Jason E. Koglin,Dominik Oberthuer,Michael Heymann,Christopher Kupitz,Chelsie E. Conrad,Jesse Coe,Shatabdi Roy-Chowdhury,Uwe Weierstall,Daniel James,Dingjie Wang,Thomas D. Grant,Anton Barty,Oleksandr Yefanov,Jennifer Scales,Cornelius Gati,Carolin Seuring,Vukica Šrajer,Robert Henning,Peter Schwander,Raimund Fromme,Abbas Ourmazd,Keith Moffat,Jasper J. van Thor,John C. H. Spence,Petra Fromme,Henry N. Chapman,Marius Schmidt +35 more
TL;DR: This work used microcrystals of photoactive yellow protein as a model system and obtained high-resolution, time-resolved difference electron density maps of excellent quality with strong features, which open the way to the study of reversible and nonreversible biological reactions on time scales as short as femtoseconds under conditions that maximize the extent of reaction initiation throughout the crystal.
Journal ArticleDOI
Serial femtosecond crystallography of G protein-coupled receptors.
Wei Liu,Daniel Wacker,Cornelius Gati,Gye Won Han,Daniel James,Dingjie Wang,Garrett Nelson,Uwe Weierstall,Vsevolod Katritch,Anton Barty,Nadia A. Zatsepin,Dianfan Li,Marc Messerschmidt,Sébastien Boutet,Garth J. Williams,Jason E. Koglin,M. Marvin Seibert,M. Marvin Seibert,Chong Wang,Syed T. A. Shah,Shibom Basu,Raimund Fromme,Christopher Kupitz,Kimberly N. Rendek,Ingo Grotjohann,Petra Fromme,Richard A. Kirian,Kenneth R. Beyerlein,Thomas A. White,Henry N. Chapman,Martin Caffrey,John C. H. Spence,Raymond C. Stevens,Vadim Cherezov +33 more
TL;DR: The structure of a human serotonin receptor was solved using a free-electron laser to analyze microcrystals and displays a distinct distribution of thermal motions and conformations of residues that likely more accurately represent the receptor structure and dynamics in a cellular environment.