F
Fabrizio Gardoni
Researcher at University of Milan
Publications - 160
Citations - 9103
Fabrizio Gardoni is an academic researcher from University of Milan. The author has contributed to research in topics: NMDA receptor & Synaptic plasticity. The author has an hindex of 50, co-authored 147 publications receiving 7877 citations. Previous affiliations of Fabrizio Gardoni include Centre national de la recherche scientifique & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases
Barbara Viviani,Stefano Bartesaghi,Fabrizio Gardoni,Annamaria Vezzani,M. Margarita Behrens,Tamas Bartfai,M. Binaglia,Emanuela Corsini,M. Di Luca,C. L. Galli,Marina Marinovich +10 more
TL;DR: The data suggest that IL-1β increases NMDA receptor function through activation of tyrosine kinases and subsequent NR2A/B subunit phosphorylation, which may contribute to glutamate-mediated neurodegeneration.
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Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.
Matthieu F. Bastide,Wassilios G. Meissner,Barbara Picconi,Stefania Fasano,Pierre-Olivier Fernagut,Michael Feyder,Veronica Francardo,Cristina Alcacer,Yunmin Ding,Riccardo Brambilla,Gilberto Fisone,A. Jon Stoessl,Mathieu Bourdenx,Michel Engeln,Sylvia Navailles,Philippe De Deurwaerdère,Wai Kin D. Ko,Nicola Simola,Micaela Morelli,Laurent Groc,Maria Cruz Rodriguez,Eugenia V. Gurevich,Maryka Quik,Michele Morari,Manuela Mellone,Fabrizio Gardoni,Elisabetta Tronci,Dominique Guehl,François Tison,Alan R. Crossman,Un Jung Kang,Kathy Steece-Collier,Susan H. Fox,Manolo Carta,M. Angela Cenci,Erwan Bezard +35 more
TL;DR: The present review attempts to provide an overview of the current understanding of dyskinesia and other L-dopa-induced dysfunctions to help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.
Journal ArticleDOI
A Critical Interaction between NR2B and MAGUK in l-DOPA Induced Dyskinesia
Fabrizio Gardoni,Barbara Picconi,Veronica Ghiglieri,Federica Polli,Vincenza Bagetta,Giorgio Bernardi,Flaminio Cattabeni,Monica Di Luca,Paolo Calabresi +8 more
TL;DR: Data indicate abnormal NR2B redistribution between synaptic and extrasynaptic membranes as an important molecular disturbance of the glutamatergic synapse involved in l-DOPA-induced dyskinesia.
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Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.
Ana Muñoz,Qin Li,Fabrizio Gardoni,Elena Marcello,Chuan Qin,Thomas Carlsson,Deniz Kirik,Monica Di Luca,Anders Björklund,Erwan Bezard,Manolo Carta +10 more
TL;DR: In this paper, the authors investigated the efficacy of 5-HT(1A) and 5-HPT(1B) agonists to counteract l-DOPA-induced dyskinesia in 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-treated macaques.
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Regulation of dopamine D1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors.
TL;DR: It is reported that, in striatal neurons, D1 receptors are co-localized with N-methyl-d-aspartate (NMDA) receptors in the postsynaptic density and that they co-immunoprecipitate with NMDA receptor subunits from post Synaptic density preparations.