Journal ArticleDOI
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.
Matthieu F. Bastide,Wassilios G. Meissner,Barbara Picconi,Stefania Fasano,Pierre-Olivier Fernagut,Michael Feyder,Veronica Francardo,Cristina Alcacer,Yunmin Ding,Riccardo Brambilla,Gilberto Fisone,A. Jon Stoessl,Mathieu Bourdenx,Michel Engeln,Sylvia Navailles,Philippe De Deurwaerdère,Wai Kin D. Ko,Nicola Simola,Micaela Morelli,Laurent Groc,Maria Cruz Rodriguez,Eugenia V. Gurevich,Maryka Quik,Michele Morari,Manuela Mellone,Fabrizio Gardoni,Elisabetta Tronci,Dominique Guehl,François Tison,Alan R. Crossman,Un Jung Kang,Kathy Steece-Collier,Susan H. Fox,Manolo Carta,M. Angela Cenci,Erwan Bezard +35 more
TLDR
The present review attempts to provide an overview of the current understanding of dyskinesia and other L-dopa-induced dysfunctions to help in the development of novel therapeutic strategies aimed at preventing the generation of dyskinetic symptoms.About:
This article is published in Progress in Neurobiology.The article was published on 2015-09-01. It has received 365 citations till now. The article focuses on the topics: Dyskinesia & Parkinson's disease.read more
Citations
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Journal ArticleDOI
Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.
Valerie Voon,Valerie Voon,T. Celeste Napier,Michael J. Frank,Véronique Sgambato-Faure,Véronique Sgambato-Faure,Anthony A. Grace,Maria C. Rodriguez-Oroz,Maria C. Rodriguez-Oroz,Jose A. Obeso,Jose A. Obeso,Erwan Bezard,Erwan Bezard,Pierre-Olivier Fernagut,Pierre-Olivier Fernagut +14 more
TL;DR: In patients with Parkinson's disease and impulse control disorders, impairments are observed across subtypes of decisional impulsivity, possibly reflecting uncertainty and the relative balance of rewards and losses.
Journal ArticleDOI
Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and Rehabilitation.
Francesca Magrinelli,Alessandro Picelli,Pierluigi Tocco,Angela Federico,L. Roncari,Nicola Smania,Giampietro Zanette,Stefano Tamburin +7 more
TL;DR: A review of the neuropathology, neuropharmacology, and neurophysiology of motor dysfunction of Parkinson's disease can be found in this article, where the authors focus on classical notions and recent insights.
Journal ArticleDOI
Gamma Oscillations in the Hyperkinetic State Detected with Chronic Human Brain Recordings in Parkinson's Disease
Nicole C. Swann,Coralie de Hemptinne,Svjetlana Miocinovic,Salman E. Qasim,Sarah S. Wang,Nathan Ziman,Jill L. Ostrem,Marta San Luciano,Nicholas B. Galifianakis,Philip A. Starr +9 more
TL;DR: This work characterized an oscillation between cortex and subcortical modulators that is associated with a serious adverse effect of therapy for Parkinson's disease: dyskinesia and suggests a possible biomarker for feedback-controlled neurostimulation to treat hyperkinetic disorders.
Journal ArticleDOI
Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts.
Alberto J. Espay,Francesca Morgante,Aristide Merola,Alfonso Fasano,Alfonso Fasano,Luca Marsili,Susan H. Fox,Susan H. Fox,Erwan Bezard,Barbara Picconi,Paolo Calabresi,Anthony E. Lang,Anthony E. Lang +12 more
TL;DR: Current and in‐development treatments for peak‐dose dyskinesia are reviewed but it is suggested that improvements in levodopa delivery alone may reduce its future prevalence.
Journal ArticleDOI
Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs.
TL;DR: The challenges associated with the development of novel therapies for Parkinson disease are discussed, highlighting emerging agents that aim to target cell death, as well as new targets offering a symptomatic approach to managing features and progression of the disease.
References
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