Szabolcs Lehel

TL;DR: The largest target-to-background binding ratio was found for [11C]Cimbi-36 which also had a high brain uptake compared to its analogues, and is currently the most promising candidate for investigation of 5-HT2A receptor agonist binding in the living human brain with PET.

TL;DR: The findings are in line with S-carriers having an increased response in neural circuits involved in emotional processing to stressful environmental stimuli but here demonstrated as a endophenotype with dynamic changes in serotonin reuptake.

TL;DR: This study is the first to demonstrate an abnormally decreased cerebral SERT binding in obese individuals and whether the SERT has a direct role in the regulation of appetite and eating behaviour or whether the finding is due to a compensatory downregulation of SERT secondary to other dysfunction(s) in the serotonergic transmitter system remains to be established.

TL;DR: The data imply both serotonergic signaling and estradiol in the mechanisms by which sex-steroid hormone fluctuations provoke depressive symptoms and thus provide a rationale for future preventive strategies in high-risk groups.

TL;DR: Cimbi-36 is described as the first agonist PET radioligand to successfully image and quantify 5-HT2A receptors in the human brain.