Journal ArticleDOI
Seasonal Changes in Brain Serotonin Transporter Binding in Short Serotonin Transporter Linked Polymorphic Region-Allele Carriers but Not in Long-Allele Homozygotes
Jan Kalbitzer,David Erritzoe,Klaus K. Holst,Finn Årup Nielsen,Finn Årup Nielsen,Lisbeth Marner,Szabolcs Lehel,Tine E. Arentzen,Terry L. Jernigan,Gitte M. Knudsen +9 more
TLDR
The findings are in line with S-carriers having an increased response in neural circuits involved in emotional processing to stressful environmental stimuli but here demonstrated as a endophenotype with dynamic changes in serotonin reuptake.About:
This article is published in Biological Psychiatry.The article was published on 2010-06-01. It has received 104 citations till now. The article focuses on the topics: Serotonin transporter & DASB.read more
Citations
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Journal ArticleDOI
Suicide and seasonality
Christos Christodoulou,Athanassios Douzenis,Fotis C. Papadopoulos,Athanasia Papadopoulou,Georgios Bouras,Rossetos Gournellis,Lefteris Lykouras +6 more
TL;DR: A study on suicide and seasonality in Cyprus found that the number of people taking their own lives during the summer months is higher than in the winter.
Journal ArticleDOI
The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis
TL;DR: A meta-analysis indicates a small, but significant association between 5-HTTLPR genotype and HPA-axis reactivity to acute psychosocial stress with homozygous carriers of the S allele displaying increased cortisol reactivity compared with individuals with the S/L and L/L genotype.
Journal ArticleDOI
Vitamin D, light and mental health
TL;DR: In adult patients, low levels have been reported, supporting the notion that vitamin D deficiency may not only be a predisposing developmental factor but also relate to the adult patients' psychiatric state.
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5-HT radioligands for human brain imaging with PET and SPECT.
TL;DR: The development of PET and SPECT radioligands to image serotonergic targets is of high interest, and successful evaluation in humans is leading to invaluable insight into normal and abnormal brain function, emphasizing the need for continued development of both SPECT and PET radiolIGands for human brain imaging.
Journal ArticleDOI
Neuroreceptor imaging in depression.
TL;DR: PET studies of neuroreceptor function in mood disorders - specifically, major depressive disorder (MDD) and bipolar disorder (BD) are reviewed and the most widely studied receptors of the serotonergic and dopaminergic systems are concentrated on.
References
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Journal ArticleDOI
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
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Nonparametric permutation tests for functional neuroimaging: A primer with examples
TL;DR: The standard nonparametric randomization and permutation testing ideas are developed at an accessible level, using practical examples from functional neuroimaging, and the extensions for multiple comparisons described.
Journal ArticleDOI
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Klaus-Peter Lesch,D. Bengel,Armin Heils,Sue Z. Sabol,Benjamin D. Greenberg,Susanne Petri,Jonathan Benjamin,Clemens R. Müller,Dean H. Hamer,Dennis L. Murphy +9 more
TL;DR: The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5HTT expression and 5HT uptake in lymphoblasts as discussed by the authors, which is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs.
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Serotonin Transporter Genetic Variation and the Response of the Human Amygdala
Ahmad R. Hariri,Venkata S. Mattay,Alessandro Tessitore,Bhaskar Kolachana,Francesco Fera,David Goldman,Michael F. Egan,Daniel R. Weinberger +7 more
TL;DR: Genetically driven variation in the response of brain regions underlying human emotional behavior is demonstrated and differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele.
Journal ArticleDOI
Seasonal Affective Disorder: A Description of the Syndrome and Preliminary Findings With Light Therapy
Norman E. Rosenthal,David A. Sack,J. Christian Gillin,Alfred J. Lewy,Frederick K. Goodwin,Yolande B. Davenport,Peter S. Mueller,David A. Newsome,Thomas A. Wehr +8 more
TL;DR: Preliminary studies in 11 patients suggest that extending the photoperiod with bright artificial light has an antidepressant effect and sleep recordings in nine depressed patients confirmed the presence of hypersomnia and showed increased sleep latency and reduced slow-wave (delta) sleep.