T
T. Toda
Researcher at Cold Spring Harbor Laboratory
Publications - 13
Citations - 3161
T. Toda is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Saccharomyces cerevisiae & Yeast. The author has an hindex of 10, co-authored 13 publications receiving 3100 citations.
Papers
More filters
Journal ArticleDOI
In yeast, RAS proteins are controlling elements of adenylate cyclase
T. Toda,Isao Uno,Tatsuo Ishikawa,Scott Powers,Tohru Kataoka,Daniel Broek,Scott J. Cameron,James R. Broach,Kunihiro Matsumoto,Michael Wigler +9 more
TL;DR: S. cerevisiae strains containing RAS2val19, a Ras2 gene with a missense mutation analogous to one that activates the transforming potential of mammalian ras genes, have growth and biochemical properties strikingly similar to yeast strains carrying IAC or bcy1.
Journal ArticleDOI
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
TL;DR: Three genes (TPK1, TPK2, and TPK3) from the yeast S. cerevisiae that encode the catalytic subunits of the cAMP-dependent protein kinase are isolated.
Journal ArticleDOI
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.
T. Toda,Scott J. Cameron,Philip M. Sass,Mark J. Zoller,John D. Scott,B. McMullen,Mary Y. Hurwitz,E G Krebs,Michael Wigler +8 more
TL;DR: Strains of S. cerevisiae with disrupted BCY1 genes do not display a cyclic AMP-dependent protein kinase in vitro, fail to grow on many carbon sources, and are exquisitely sensitive to heat shock and starvation.
Journal ArticleDOI
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
Daniel Broek,T. Toda,T. Michaeli,Lonny R. Levin,C. Birchmeier,Mark J. Zoller,Scott Powers,Michael Wigler +7 more
TL;DR: It is proposed that CDC25 regulates adenylate cyclase by regulating the guanine nucleotide bound to RAS proteins, suggesting that normal RAS is dependent on CDC25 function.
Journal ArticleDOI
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae.
TL;DR: In this paper, normal and mutant alleles of many genes of the RAS/adenylyl cyclase pathway of the yeast Saccharomyces cerevisiae were identified.