T
T. Michaeli
Researcher at Cold Spring Harbor Laboratory
Publications - 14
Citations - 1830
T. Michaeli is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Mutant & Saccharomyces cerevisiae. The author has an hindex of 11, co-authored 14 publications receiving 1796 citations.
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Journal ArticleDOI
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
Daniel Broek,T. Toda,T. Michaeli,Lonny R. Levin,C. Birchmeier,Mark J. Zoller,Scott Powers,Michael Wigler +7 more
TL;DR: It is proposed that CDC25 regulates adenylate cyclase by regulating the guanine nucleotide bound to RAS proteins, suggesting that normal RAS is dependent on CDC25 function.
Journal ArticleDOI
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
Graeme Bolger,T. Michaeli,T. Martins,T. St John,B. Steiner,Linda Rodgers,Michael Riggs,Michael Wigler,K. Ferguson +8 more
TL;DR: Four human genes (DPDE1 through DPDE4) closely related to the dnc learning and memory locus of Drosophila melanogaster are isolated and shown to encode cyclic AMP-specific phosphodiesterases.
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Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein
Jeffrey Field,Anne Vojtek,R. Ballester,Graeme Bolger,John J. Colicelli,K. Ferguson,Jeffrey E. Gerst,Tohru Kataoka,T. Michaeli,Scott Powers,Michael Riggs,Linda Rodgers,Ilse Wieland,B. Wheland,Michael Wigler +14 more
TL;DR: The results suggest that CAP is required for at least some aspects of the RAS-responsive signaling system, including the inability to grow on rich medium (YPD), temperature sensitivity on minimal medium, sensitivity to nitrogen starvation, and a swollen cell morphology.
Journal ArticleDOI
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.
T. Michaeli,T. J. Bloom,T. Martins,K. Loughney,K. Ferguson,Michael Riggs,Linda Rodgers,J. A. Beavo,Michael Wigler +8 more
TL;DR: The biochemical and pharmacological properties of HCP1 suggest that it is a member of a previously undiscovered cyclic nucleotide PDE family, and northern blot analysis indicates that high levels of H CP1 mRNA are present in human skeletal muscle.
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Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase
TL;DR: It is shown that the DPD protein is a high-affinity cAMP-specific phosphodiesterase, a mutant form of the RAS2 gene analogous to an oncogenic mutant of the human HRAS gene.