M
Mark J. Zoller
Researcher at ARIAD Pharmaceuticals, Inc.
Publications - 28
Citations - 3553
Mark J. Zoller is an academic researcher from ARIAD Pharmaceuticals, Inc.. The author has contributed to research in topics: Protein kinase A & Protein subunit. The author has an hindex of 20, co-authored 28 publications receiving 3502 citations. Previous affiliations of Mark J. Zoller include Cold Spring Harbor Laboratory & University of California, San Diego.
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Journal ArticleDOI
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
TL;DR: Three genes (TPK1, TPK2, and TPK3) from the yeast S. cerevisiae that encode the catalytic subunits of the cAMP-dependent protein kinase are isolated.
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Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.
T. Toda,Scott J. Cameron,Philip M. Sass,Mark J. Zoller,John D. Scott,B. McMullen,Mary Y. Hurwitz,E G Krebs,Michael Wigler +8 more
TL;DR: Strains of S. cerevisiae with disrupted BCY1 genes do not display a cyclic AMP-dependent protein kinase in vitro, fail to grow on many carbon sources, and are exquisitely sensitive to heat shock and starvation.
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The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
Daniel Broek,T. Toda,T. Michaeli,Lonny R. Levin,C. Birchmeier,Mark J. Zoller,Scott Powers,Michael Wigler +7 more
TL;DR: It is proposed that CDC25 regulates adenylate cyclase by regulating the guanine nucleotide bound to RAS proteins, suggesting that normal RAS is dependent on CDC25 function.
Journal ArticleDOI
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae
TL;DR: The results indicate that cAMP-independent mechanisms must exist for regulating glycogen accumulation, sporulation, and the acquisition of thermotolerance in S. cerevisiae.
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The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain.
John D. Scott,Moira B. Glaccum,Mark J. Zoller,Michael D. Uhler,David M. Helfman,G S McKnight,E G Krebs +6 more
TL;DR: A cDNA clone for a type II regulatory (R) subunit of the cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37) was isolated from a rat skeletal muscle library using a specific 47-base oligonucleotide probe.