T
Takahiro Matsumoto
Researcher at University of Tokyo
Publications - 58
Citations - 5961
Takahiro Matsumoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Androgen receptor & Androgen. The author has an hindex of 32, co-authored 56 publications receiving 5522 citations. Previous affiliations of Takahiro Matsumoto include University of Tokushima.
Papers
More filters
Journal ArticleDOI
Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts
Takashi Nakamura,Yuuki Imai,Yuuki Imai,Takahiro Matsumoto,Shingo Sato,Kazusane Takeuchi,Katsuhide Igarashi,Yoshifumi Harada,Yoshiaki Azuma,Andrée Krust,Yoko Yamamoto,Hiroshi Nishina,Shu Takeda,Hiroshi Takayanagi,Daniel Metzger,Jun Kanno,Kunio Takaoka,T. John Martin,Pierre Chambon,Shigeaki Kato +19 more
TL;DR: A model in which estrogen regulates the life span of mature osteoclasts via the induction of the Fas/FasL system is supported, thereby providing an explanation for the osteoprotective function of estrogen as well as SERMs.
Journal ArticleDOI
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor.
Fumiaki Ohtake,Ken-ichi Takeyama,Takahiro Matsumoto,Hirochika Kitagawa,Yasuji Yamamoto,Keiko Nohara,Chiharu Tohyama,Andrée Krust,Junsei Mimura,Pierre Chambon,Junn Yanagisawa,Yoshiaki Fujii-Kuriyama,Shigeaki Kato +12 more
TL;DR: It is shown that the agonist-activated AhR/Arnt heterodimer directly associates with oestrogen receptors ER-α and ER-β, which results in the recruitment of unliganded ER and the co-activator p300 to ostrogen-responsive gene promoters, leading to activation of transcription and oestrogensic effects.
Journal ArticleDOI
DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs
Toru Fukuda,Kaoru Yamagata,Sally Fujiyama,Takahiro Matsumoto,Iori Koshida,Kimihiro Yoshimura,Masatomo Mihara,Masanori Naitou,Hideki Endoh,Takashi Nakamura,Chihiro Akimoto,Yoko Yamamoto,Takenobu Katagiri,Charles E. Foulds,Shinichiro Takezawa,Hirochika Kitagawa,Ken-ichi Takeyama,Bert W. O'Malley,Shigeaki Kato +18 more
TL;DR: It is suggested that DEAD-box RNA helicase subunits are required for recognition of a subset of primary miRNAs in mDrosha-mediated processing.
Journal ArticleDOI
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice.
Kimiko Yamamoto,Takaaki Sokabe,Takahiro Matsumoto,Kimihiro Yoshimura,Masahiro Shibata,Norihiko Ohura,Toru Fukuda,Takashi Sato,Keisuke Sekine,Shigeaki Kato,Masashi Isshiki,Toshiro Fujita,Mikio Kobayashi,Koichi Kawamura,Hirotake Masuda,Akira Kamiya,Joji Ando +16 more
TL;DR: It is shown that the ATP-gated P2X4 ion channel, expressed on endothelial cells and encoded by P2rx4 in mice, has a key role in the response of endothelium cells to changes in blood flow.
Journal ArticleDOI
Premature ovarian failure in androgen receptor-deficient mice
Hiroko Shiina,Takahiro Matsumoto,Takashi Sato,Katsuhide Igarashi,Junko Miyamoto,Sayuri Takemasa,Matomo Sakari,Ichiro Takada,Takashi Nakamura,Daniel Metzger,Pierre Chambon,Jun Kanno,Hiroyuki Yoshikawa,Shigeaki Kato +13 more
TL;DR: It is suggested that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome.