Takashi Imai

TL;DR: This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies.

TL;DR: In cisplatin-resistant HeLa cisR cells, fibroblast growth factor 13 gene and protein expression was strongly upregulated, and intracellular platinum concentrations were kept low, suggesting FGF13 plays a pivotal role in mediating resistance to platinum drugs, possibly via a mechanism shared by platinum and copper.

TL;DR: Investigation of the effect of irradiation on amoeboid motility by using cells of the human pancreatic cancer line, MIAPaCa‐2, suggests that ROCKI treatment, especially with concomitant X‐ray irradiation, can induce invasion of cancer cells and should be used only for certain types ofcancer cells.

TL;DR: This study revealed significant C-ion induced upregulation of stress-responsive and cell-communication genes common to different tumor types, providing evidence for the efficacy of this modality for the treatment of local tumors.

TL;DR: C‐ion irradiation is effective in suppressing the invasive potential of several pancreatic tumor cell lines, but not PANC‐1; this is the first study showing that C‐ions irradiation induces the invasive Potential of a tumor cell line.