N
Nawaid Usmani
Researcher at Cross Cancer Institute
Publications - 150
Citations - 2902
Nawaid Usmani is an academic researcher from Cross Cancer Institute. The author has contributed to research in topics: Prostate cancer & Prostate brachytherapy. The author has an hindex of 23, co-authored 130 publications receiving 1973 citations. Previous affiliations of Nawaid Usmani include University of Alberta & Queen's University.
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Journal ArticleDOI
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Fredrick R. Schumacher,Ali Amin Al Olama,Sonja I. Berndt,Sara Benlloch,Mahbubl Ahmed,Edward J. Saunders,Tokhir Dadaev,Daniel Leongamornlert,Ezequiel Anokian,Clara Cieza-Borrella,Chee Goh,Mark N. Brook,Xin Sheng,Laura Fachal,Joe Dennis,Jonathan Tyrer,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Artitaya Lophatananon,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Jyotsna Batra,Jyotsna Batra,Suzanne K. Chambers,Suzanne K. Chambers,Leire Moya,Leire Moya,Judith A. Clements,Judith A. Clements,Lisa G. Horvath,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Tobias Nordström,Paul D.P. Pharoah,Nora Pashayan,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Demetrius Albanes,Stephanie J. Weinstein,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Catharine M L West,Alison M. Dunning,Neil G. Burnet,Lorelei A. Mucci,Edward Giovannucci,Gerald L. Andriole,Olivier Cussenot,Geraldine Cancel-Tassin,Stella Koutros,Laura E. Beane Freeman,Karina Dalsgaard Sørensen,Torben F. Ørntoft,Michael Borre,Lovise Maehle,Eli Marie Grindedal,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Ruth C. Travis,Timothy J. Key,Robert J. Hamilton,Neil E. Fleshner,Antonio Finelli,Sue A. Ingles,Mariana C. Stern,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Xin Guo,Guomin Wang,Zan Sun,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Liesel M. FitzGerald,Liesel M. FitzGerald,Adam S. Kibel,Bettina F. Drake,Ana Vega,Antonio Gómez-Caamaño,Robert Szulkin,Martin Eklund,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Kathryn L. Penney,Meir J. Stampfer,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Janet L. Stanford,Janet L. Stanford,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,Elaine A. Ostrander,Milan S. Geybels,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Rasmus Bisbjerg,Martin Andreas Røder,Peter Iversen,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Christiane Maier,Manuel Luedeke,Thomas J. Schnoeller,Jeri Kim,Christopher J. Logothetis,Esther M. John,Esther M. John,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Marta Cardoso,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,Kim De Ruyck,Gert De Meerleer,Piet Ost,Azad Hassan Abdul Razack,Jasmine Lim,Soo Hwang Teo,Daniel W. Lin,Daniel W. Lin,Lisa F. Newcomb,Lisa F. Newcomb,Davor Lessel,Marija Gamulin,Tomislav Kuliš,Radka Kaneva,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Sandeep Singhal,Chavdar Slavov,Vanio Mitev,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Samantha E.T. Larkin,Paul A. Townsend,Claire Aukim-Hastie,Manuela Gago Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Jianfeng Xu,Kay-Tee Khaw,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hardev Pandha,Agnieszka Michael,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Sara Lindström,Constance Turman,Jing Ma,David J. Hunter,Elio Riboli,A. Siddiq,Federico Canzian,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Zuxi Cui,Peter Kraft,Christopher I. Amos,David V. Conti,Douglas F. Easton,Fredrik Wiklund,Stephen J. Chanock,Brian E. Henderson,Zsofia Kote-Jarai,Christopher A. Haiman,Rosalind A. Eeles +207 more
TL;DR: A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.
Journal ArticleDOI
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
David V. Conti,Burcu F. Darst,Lilit C. Moss,Edward J. Saunders,Xin Sheng,Alisha Chou,Fredrick R. Schumacher,Ali Amin Al Olama,Sara Benlloch,Tokhir Dadaev,Mark N. Brook,Ali Sahimi,Thomas J. Hoffmann,Atushi Takahashi,Koichi Matsuda,Yukihide Momozawa,Masashi Fujita,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Peggy Wan,Loic Le Marchand,Lynne R. Wilkens,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Graham G. Giles,Graham G. Giles,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Stig E. Bojesen,Martin Andreas Røder,Peter Iversen,Jyotsna Batra,Suzanne K. Chambers,Leire Moya,Lisa G. Horvath,Judith A. Clements,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Robert Szulkin,Martin Eklund,Tobias Nordström,Nora Pashayan,Alison M. Dunning,Maya Ghoussaini,Ruth C. Travis,Timothy J. Key,Elio Riboli,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Demetrius Albanes,Stephanie J. Weinstein,Lorelei A. Mucci,Edward Giovannucci,Sara Lindström,Peter Kraft,David J. Hunter,Kathryn L. Penney,Constance Turman,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Robert J. Hamilton,Robert J. Hamilton,Neil Fleshner,Antonio Finelli,Marie-Élise Parent,Marie-Élise Parent,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Milan S. Geybels,Stella Koutros,Laura E. Beane Freeman,Meir J. Stampfer,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Gerald L. Andriole,Robert N. Hoover,Mitchell J. Machiela,Karina Dalsgaard Sørensen,Michael Borre,William J. Blot,Wei Zheng,Edward D. Yeboah,Edward D. Yeboah,James E. Mensah,James E. Mensah,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Yudong Wu,Shan Chao Zhao,Zan Sun,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Catharine M L West,Neil G. Burnet,Gill Barnett,Christiane Maier,Thomas J. Schnoeller,Manuel Luedeke,Adam S. Kibel,Bettina F. Drake,Olivier Cussenot,Geraldine Cancel-Tassin,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Esther M. John,Eli Marie Grindedal,Lovise Maehle,Kay-Tee Khaw,Sue A. Ingles,Mariana C. Stern,Ana Vega,Antonio Gómez-Caamaño,Laura Fachal,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Andreia Brandão,Stephen Watya,Alexander Lubwama,Jeannette T. Bensen,Elizabeth T. H. Fontham,James L. Mohler,James L. Mohler,Jack A. Taylor,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Craig C. Teerlink,Craig C. Teerlink,Chad D. Huff,Sara S. Strom,Luc Multigner,Pascal Blanchet,Laurent Brureau,Radka Kaneva,Chavdar Slavov,Vanio Mitev,Robin J. Leach,Brandi Weaver,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Kai Uwe Saum,Eric A. Klein,Ann W. Hsing,Rick A. Kittles,Adam B. Murphy,Christopher J. Logothetis,Jeri Kim,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,William B. Isaacs,Barbara Nemesure,Anselm Hennis,Anselm Hennis,John D. Carpten,Hardev Pandha,Agnieszka Michael,Kim De Ruyck,Gert De Meerleer,Piet Ost,Jianfeng Xu,Azad Hassan Abdul Razack,Jasmine Lim,Soo-Hwang Teo,Lisa F. Newcomb,Daniel W. Lin,Jay H. Fowke,Christine Neslund-Dudas,Benjamin A. Rybicki,Marija Gamulin,Davor Lessel,Tomislav Kuliš,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Manuela Gago-Dominguez,Manuela Gago-Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Samantha E.T. Larkin,Paul A. Townsend,Paul A. Townsend,Claire Aukim-Hastie,William S. Bush,Melinda C. Aldrich,Dana C. Crawford,Shiv Srivastava,Jennifer Cullen,Gyorgy Petrovics,Graham Casey,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Jennifer J. Hu,Maureen Sanderson,Rohit Varma,Roberta McKean-Cowdin,Mina Torres,Nicholas Mancuso,Sonja I. Berndt,Stephen K. Van Den Eeden,Stephen K. Van Den Eeden,Douglas F. Easton,Stephen J. Chanock,Michael B. Cook,Fredrik Wiklund,Hidewaki Nakagawa,John S. Witte,Rosalind A. Eeles,Rosalind A. Eeles,Zsofia Kote-Jarai,Christopher A. Haiman +254 more
TL;DR: This paper conducted a meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants.
Journal ArticleDOI
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Tokhir Dadaev,Edward J. Saunders,Paul J. Newcombe,Ezequiel Anokian,Daniel Leongamornlert,Mark N. Brook,Clara Cieza-Borrella,Martina Mijušković,Sarah Wakerell,Ali Amin Al Olama,Fredrick R. Schumacher,Sonja I. Berndt,Sara Benlloch,Mahbubl Ahmed,Chee Goh,Xin Sheng,Zhuo Zhang,Kenneth Muir,Kenneth Muir,Koveela Govindasami,Artitaya Lophatananon,Artitaya Lophatananon,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Jyotsna Batra,Jyotsna Batra,Suzanne K. Chambers,Leire Moya,Leire Moya,Judith A. Clements,Judith A. Clements,Lisa G. Horvath,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Tobias Nordström,Paul D.P. Pharoah,Nora Pashayan,Nora Pashayan,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Demetrius Albanes,Stephanie J. Weinstein,Alicja Wolk,Niclas Håkansson,Catharine M L West,Alison M. Dunning,Neil G. Burnet,Lorelei A. Mucci,Edward Giovannucci,Gerald L. Andriole,Olivier Cussenot,Geraldine Cancel-Tassin,Stella Koutros,Laura E. Beane Freeman,Karina Dalsgaard Sørensen,Torben F. Ørntoft,Michael Borre,Lovise Maehle,Eli Marie Grindedal,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Ruth C. Travis,Timothy J. Key,Robert J. Hamilton,Neil E. Fleshner,Antonio Finelli,Sue A. Ingles,Mariana C. Stern,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Xin Guo,Xin Guo,Guomin Wang,Zan Sun,Graham G. Giles,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Liesel M. FitzGerald,Liesel M. FitzGerald,Adam S. Kibel,Bettina F. Drake,Ana Vega,Antonio Gómez-Caamaño,Laura Fachal,Robert Szulkin,Martin Eklund,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Kathryn L. Penney,Meir J. Stampfer,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Janet L. Stanford,Janet L. Stanford,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,Elaine A. Ostrander,Milan S. Geybels,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weisher,Rasmus Bisbjerg,Martin Andreas Røder,Peter Iversen,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Christiane Maier,Manuel Luedeke,Thomas J. Schnoeller,Jeri Kim,Christopher J. Logothetis,Esther M. John,Esther M. John,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Marta Cardoso,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,Kim De Ruyck,Gert De Meerleer,Piet Ost,Azad Hassan Abdul Razack,Jasmine Lim,Soo-Hwang Teo,Daniel W. Lin,Daniel W. Lin,Lisa F. Newcomb,Lisa F. Newcomb,Davor Lessel,Marija Gamulin,Tomislav Kuliš,Radka Kaneva,Nawaid Usmani,Nawaid Usmani,Chavdar Slavov,Vanio Mitev,Matthew Parliament,Matthew Parliament,Sandeep Singhal,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Samantha E.T. Larkin,Paul A. Townsend,Claire Aukim-Hastie,Manuela Gago-Dominguez,Manuela Gago-Dominguez,Jose E. Castelao,Maria Elena Martinez,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Jianfeng Xu,Kay-Tee Khaw,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hardev Pandha,Agnieszka Michael,Andrzej M. Kierzek,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Sara Lindström,Constance Turman,Jing Ma,David J. Hunter,Elio Riboli,A. Siddiq,Federico Canzian,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Peter Kraft,Margaret Cook,Alison Thwaites,Michelle Guy,Ian Whitmore,Angela Morgan,Cyril Fisher,Steve Hazel,Naomi Livni,Amanda B. Spurdle,Srilakshmi Srinivasan,Srilakshmi Srinivasan,Mary A. Kedda,Mary A. Kedda,Joanne F. Aitken,Robert A. Gardiner,Robert A. Gardiner,Vanessa M. Hayes,Lisa M. Butler,Renea A. Taylor,Trina Yeadon,Trina Yeadon,A. L. Eckert,A. L. Eckert,Pamela Saunders,Anne Maree Haynes,Melissa Papargiris,Paula Kujala,Kirsi Talala,Teemu J. Murtola,Kimmo Taari,David P. Dearnaley,Gill Barnett,Søren M. Bentzen,Rebecca Elliott,Hardeep Ranu,Belynda Hicks,Aurelie Vogt,Amy Hutchinson,Angela Cox,Michael Davis,Paul M. Brown,Anne George,G Marsden,Athene Lane,Sarah J Lewis,Clare Berry,Girish S. Kulkarni,Ants Toi,Andrew Evans,Alexandre R. Zlotta,Theodorus van der Kwast,Takashi Imai,Shiro Saito,Jacek Marzec,Guangwen Cao,Ji Lin,Jin Ling,Meiling Li,Shan Chao Zhao,Guoping Ren,Yongwei Yu,Yudong Wu,Ji Wu,Bo Zhou,Yangling Zhang,Jie Li,Weiyang He,Jianming Guo,John Pedersen,John L. Hopper,Roger L. Milne,Roger L. Milne,Aleksandra Klim,Ana Carballo,Ramón Lobato-Busto,Paula Peleteiro,Patricia Calvo,Miguel Aguado,José Manuel Ruiz-Dominguez,Lluís Cecchini,Lourdes Mengual,Antonio Alcaraz,Mariona Bustamante,Esther Gracia-Lavedan,Trinidad Dierssen-Sotos,Inés Gómez-Acebo,Julio M. Pow-Sang,Hyun Ik Park,Babu Zachariah,Wojciech Kluzniak,Suzanne Kolb,Peter Klarskov,Christa Stegmaier,Walther Vogel,Kathleen Herkommer,Philipp Bohnert,Sofia Maia,Maria P. Silva,Sofie De Langhe,Hubert Thierens,Meng H. Tan,Aik T. Ong,Zeljko Kastelan,Elenko Popov,Darina Kachakova,Atanaska Mitkova,Aleksandrina Vlahova,Tihomir Dikov,Svetlana Christova,Angel Carracedo,Angel Carracedo,C.H. Bangma,Fritz H. Schröder,Sylvie Cénée,Brigitte Trétarre,Xavier Rebillard,Claire Mulot,Marie Sanchez,Jan Adolfsson,Pär Stattin,Pär Stattin,Jan-Erik Johansson,Carin Cavalli-Bjoerkman,Ami Karlsson,Michael Broms,Huihai Wu,Lori S. Tillmans,Shaun M. Riska,Matthew L. Freedman,Fredrik Wiklund,Stephen J. Chanock,Brian E. Henderson,Douglas F. Easton,Christopher A. Haiman,Rosalind A. Eeles,David V. Conti,Zsofia Kote-Jarai +339 more
TL;DR: The authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.
Journal ArticleDOI
Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD).
Delphine Lechardeur,Luke Drzymala,Manu Sharma,Danuta Zylka,Robert Kinach,Joanna Pacia,Christopher Hicks,Nawaid Usmani,Johanna M. Rommens,Gergely L. Lukacs +9 more
TL;DR: A complex mechanism, involving the recognition of the NLSs of both ICAD and CAD, accounts for the constitutive accumulation of CAD/ICAD in the nucleus, where caspase-3–dependent regulation of CAD activity takes place.
Journal ArticleDOI
The 2015 CUA-CUOG Guidelines for the management of castration-resistant prostate cancer (CRPC)
Fred Saad,Kim N. Chi,Antonio Finelli,Sebastien J. Hotte,Jonathan I. Izawa,Anil Kapoor,Wassim Kassouf,Andrew Loblaw,Scott North,Ricardo A. Rendon,Alan So,Nawaid Usmani,Eric Vigneault,Neil Fleshner +13 more
TL;DR: Agents that have shown improvements in survival in mCRPC now include abiraterone, enzalutamide, docetaxel, cabazitaxel and radium-223.