Paula Peleteiro

TL;DR: It is suggested that the TANC1 locus influences the development of late radiation-induced damage in prostate cancer patients treated with external beam radiotherapy and in regenerating damaged muscle.

TL;DR: The authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

TL;DR: This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies.

TL;DR: The results show that heterogeneous radiotherapy cohorts can be combined to identify new moderate-penetrance genetic variants associated with radiotherapy toxicity, and provides a basis for larger collaborative efforts to identify enough variants for a future test involving polygenic risk profiling.

TL;DR: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers and will also enable a better understanding of how many people suffer with radiotherapy toxicity.