T
Takashi Nomura
Researcher at Kyoto University
Publications - 160
Citations - 28462
Takashi Nomura is an academic researcher from Kyoto University. The author has contributed to research in topics: Medicine & Cytotoxic T cell. The author has an hindex of 34, co-authored 141 publications receiving 26095 citations. Previous affiliations of Takashi Nomura include Daikin & Takeda Pharmaceutical Company.
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Journal ArticleDOI
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
TL;DR: Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
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Regulatory T Cells and Immune Tolerance
TL;DR: The cellular and molecular basis of Treg development and function is revealed and dysregulation of T Regs in immunological disease is implicates.
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CTLA-4 Control over Foxp3+ Regulatory T Cell Function
Kajsa Wing,Yasushi Onishi,Yasushi Onishi,Paz Prieto-Martin,Tomoyuki Yamaguchi,Makoto Miyara,Zoltan Fehervari,Takashi Nomura,Shimon Sakaguchi,Shimon Sakaguchi +9 more
TL;DR: It is shown that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell–mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice.
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Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
Makoto Miyara,Yumiko Yoshioka,Akihiko Kitoh,Tomoko Shima,Kajsa Wing,Akira Niwa,Christophe Parizot,Cécile Taflin,Toshio Heike,Dominique Valeyre,Alexis Mathian,Tatsutoshi Nakahata,Tomoyuki Yamaguchi,Takashi Nomura,Masahiro Ono,Zahir Amoura,Guy Gorochov,Guy Gorochov,Shimon Sakaguchi,Shimon Sakaguchi +19 more
TL;DR: The dissection of FoxP3(+) cells into subsets enables one to analyze Treg cell differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP 3(+) subpopulations.
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Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.
Shimon Sakaguchi,Noriko Sakaguchi,Jun Shimizu,Sayuri Yamazaki,Toshiko Sakihama,Misako Itoh,Yuhshi Kuniyasu,Takashi Nomura,Masaaki Toda,Takeshi Takahashi +9 more
TL;DR: There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells contributes to the maintenance of immunologic self‐tolerance and its alteration can cause autoimmune disease.