T
Takashi Tsukamoto
Researcher at Johns Hopkins University
Publications - 91
Citations - 4465
Takashi Tsukamoto is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Glutamate carboxypeptidase II & Glutaminase. The author has an hindex of 29, co-authored 78 publications receiving 3802 citations. Previous affiliations of Takashi Tsukamoto include Johns Hopkins University School of Medicine & Chiba University.
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Journal ArticleDOI
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
Mariia Yuneva,Teresa W.-M. Fan,Thaddeus D. Allen,Richard M. Higashi,Dana Ferraris,Takashi Tsukamoto,José M. Matés,Francisco J. Alonso,Chunmei Wang,Youngho Seo,Xin Chen,J. Michael Bishop +11 more
TL;DR: The results suggest that the metabolic profiles of tumors are likely to depend on both the genotype and tissue of origin and have implications regarding the design of therapies targeting tumor metabolism.
Journal ArticleDOI
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Meghan J. Seltzer,Bryson D. Bennett,Avadhut D. Joshi,Ping Gao,Ajit G. Thomas,Dana Ferraris,Takashi Tsukamoto,Camilo Rojas,Barbara S. Slusher,Joshua D. Rabinowitz,Chi V. Dang,Gregory J. Riggins +11 more
TL;DR: The ability to selectively slow growth in cells with IDH1 mutations by inhibiting glutaminase suggests a unique reprogramming of intermediary metabolism and a potential therapeutic strategy.
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Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)
Mary M. Robinson,Steven J. McBryant,Takashi Tsukamoto,Camilo Rojas,Dana Ferraris,Sean K. Hamilton,Jeffrey C. Hansen,Norman P. Curthoys +7 more
TL;DR: BPTES is a unique and potent inhibitor of rat KGA and elucidates a novel mechanism of inactivation, which established that BPTES prevents the formation of large phosphate-induced oligomers and instead promotes theformation of a single oligomeric species with distinct physical properties.
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Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Lifeng Yang,Tyler J. Moss,Lingegowda S. Mangala,Juan C. Marini,Hongyun Zhao,Stephen Wahlig,Stephen Wahlig,Guillermo N. Armaiz-Pena,Dahai Jiang,Abhinav Achreja,Julia Win,Rajesha Roopaimoole,Cristian Rodriguez-Aguayo,Imelda Mercado-Uribe,Gabriel Lopez-Berestein,Jinsong Liu,Takashi Tsukamoto,Anil K. Sood,Prahlad T. Ram,Deepak Nagrath +19 more
TL;DR: It is found that low‐invasive ovarian cancer (OVCA) cells are glutamine independent, whereas high-invasive OVCA cells are markedly glutamine dependent, and the ratio of gene expression associated with glutamine anabolism versus catabolism has emerged as a novel biomarker for patient prognosis.
Journal ArticleDOI
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
Jeroen R. Mesters,Cyril Barinka,Weixing Li,Takashi Tsukamoto,Pavel Majer,Barbara S. Slusher,Jan Konvalinka,Rolf Hilgenfeld +7 more
TL;DR: Three‐dimensional structures presented here reveal an induced‐fit substrate‐binding mode of this key enzyme and provide essential information for the design of GCPII inhibitors useful in the treatment of neuronal diseases and prostate cancer.