Takeshi Kameyama

TL;DR: Type III but not type I interferons are predominantly induced in human primary hepatocytes in response to HBV infection, through retinoic acid-inducible gene-I (RIG-I)-mediated sensing of the 5'-ε region of HBV pregenomic RNA.

TL;DR: ZAPS was selectively induced by 5′-triphosphate–modified RNA (3pRNA) and functioned as a potent stimulator of interferon responses in human cells mediated by the RNA helicase RIG-I, suggesting its possible use as a therapeutic target for viral control.

TL;DR: It is demonstrated that constitutive AHR signaling negatively regulates the type I interferon (IFN-I) response during infection with various types of virus and suggests that the AHR-TIPARP axis is a potential therapeutic target for enhancing antiviral responses.

TL;DR: Inhibition of the expression of mir-485 markedly reduced the replication of Newcastle disease virus and the H5N1 strain of influenza virus in mammalian cells, highlighting the dual role of miR-485 in preventing spurious activation of antiviral signaling and restricting influenza virus infection.

TL;DR: Findings indicate that the p53 mutants have a different quality in GOF activities even if the mutations occurred at the same codon, and detailed information of the status of p53, including transdominancy and GOF activity, is expected to be useful for diagnosis and therapeutic strategy fitting the individual patients.