T
Takeshi Kameyama
Researcher at Hokkaido University
Publications - 17
Citations - 1094
Takeshi Kameyama is an academic researcher from Hokkaido University. The author has contributed to research in topics: Innate immune system & Viral replication. The author has an hindex of 11, co-authored 15 publications receiving 891 citations.
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Journal ArticleDOI
The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus
Seiichi Sato,Kai Li,Takeshi Kameyama,Takaya Hayashi,Yuji Ishida,Shuko Murakami,Tsunamasa Watanabe,Sayuki Iijima,Yu Sakurai,Koichi Watashi,Susumu Tsutsumi,Yusuke Sato,Hidetaka Akita,Takaji Wakita,Charles M. Rice,Hideyoshi Harashima,Michinori Kohara,Yasuhito Tanaka,Akinori Takaoka +18 more
TL;DR: Type III but not type I interferons are predominantly induced in human primary hepatocytes in response to HBV infection, through retinoic acid-inducible gene-I (RIG-I)-mediated sensing of the 5'-ε region of HBV pregenomic RNA.
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ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses
Sumio Hayakawa,Souichi Shiratori,Hiroaki Yamato,Takeshi Kameyama,Chihiro Kitatsuji,Fumi Kashigi,Showhey Goto,Shoichiro Kameoka,Daisuke Fujikura,Taisho Yamada,Tatsuaki Mizutani,Mika Kazumata,Maiko Sato,Junji Tanaka,Masahiro Asaka,Yusuke Ohba,Tadaaki Miyazaki,Masahiro Imamura,Akinori Takaoka +18 more
TL;DR: ZAPS was selectively induced by 5′-triphosphate–modified RNA (3pRNA) and functioned as a potent stimulator of interferon responses in human cells mediated by the RNA helicase RIG-I, suggesting its possible use as a therapeutic target for viral control.
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Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense.
Taisho Yamada,Hiromasa Horimoto,Takeshi Kameyama,Sumio Hayakawa,Hiroaki Yamato,Masayoshi Dazai,Ayato Takada,Hiroshi Kida,Debbie Bott,Angela C. Zhou,David Hutin,Tania H. Watts,Masahiro Asaka,Jason Matthews,Jason Matthews,Akinori Takaoka +15 more
TL;DR: It is demonstrated that constitutive AHR signaling negatively regulates the type I interferon (IFN-I) response during infection with various types of virus and suggests that the AHR-TIPARP axis is a potential therapeutic target for enhancing antiviral responses.
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The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication
Harshad Ingle,Sushil Kumar,Ashwin Ashok Raut,Anamika Mishra,Diwakar D. Kulkarni,Takeshi Kameyama,Akinori Takaoka,Shizuo Akira,Himanshu Kumar,Himanshu Kumar +9 more
TL;DR: Inhibition of the expression of mir-485 markedly reduced the replication of Newcastle disease virus and the H5N1 strain of influenza virus in mammalian cells, highlighting the dual role of miR-485 in preventing spurious activation of antiviral signaling and restricting influenza virus infection.
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Mutant p53 R248Q but not R248W enhances in vitro invasiveness of human lung cancer NCI-H1299 cells
Kazuhito Yoshikawa,Jun-ichi Hamada,Mitsuhiro Tada,Takeshi Kameyama,Koji Nakagawa,Yukiko Suzuki,Mayumi Ikawa,Nur Mohammad Monsur Hassan,Yoshimasa Kitagawa,Tetsuya Moriuchi +9 more
TL;DR: Findings indicate that the p53 mutants have a different quality in GOF activities even if the mutations occurred at the same codon, and detailed information of the status of p53, including transdominancy and GOF activity, is expected to be useful for diagnosis and therapeutic strategy fitting the individual patients.