T
Takuya Nakayama
Researcher at University of Virginia
Publications - 55
Citations - 5128
Takuya Nakayama is an academic researcher from University of Virginia. The author has contributed to research in topics: Gene & Xenopus. The author has an hindex of 25, co-authored 48 publications receiving 4731 citations. Previous affiliations of Takuya Nakayama include Hokkaido University & National Institute for Basic Biology, Japan.
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Journal ArticleDOI
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
Atsuhito Nakao,Mozhgan Afrakhte,Anita Morn,Takuya Nakayama,Jan L. Christian,Rainer Heuchel,Susumu Itoh,Masahiro Kawabata,Nils-Erik Heldin,Carl-Henrik Heldin,Peter ten Dijke +10 more
TL;DR: In this paper, the authors reported the identification of Smad7, which is related to Smad6 (ref. 13) and showed that TGF-β-mediated phosphorylation of two proteins, Smad2 and Smad3, is inhibited by Smad-7, indicating that the antagonistic effect of the protein is exerted at this important regulatory step.
Journal ArticleDOI
Genome evolution in the allotetraploid frog Xenopus laevis
Adam M. Session,Adam M. Session,Yoshinobu Uno,Taejoon Kwon,Taejoon Kwon,Jarrod Chapman,Atsushi Toyoda,Shuji Takahashi,Akimasa Fukui,Akira Hikosaka,Atsushi Suzuki,Mariko Kondo,Simon J. van Heeringen,Ian K. Quigley,Sven Heinz,Hajime Ogino,Haruki Ochi,Uffe Hellsten,Jessica B. Lyons,Oleg Simakov,Nicholas H. Putnam,Jonathan C. Stites,Yoko Kuroki,Toshiaki Tanaka,Tatsuo Michiue,Minoru Watanabe,Ozren Bogdanovic,Ryan Lister,Georgios Georgiou,Sarita S. Paranjpe,Ila van Kruijsbergen,Shengquiang Shu,Joseph W. Carlson,Tsutomu Kinoshita,Yuko Ohta,Shuuji Mawaribuchi,Jerry Jenkins,Jane Grimwood,Jeremy Schmutz,Therese Mitros,Sahar V. Mozaffari,Yutaka Suzuki,Yoshikazu Haramoto,Takamasa S. Yamamoto,Chiyo Takagi,Rebecca Heald,Kelly E. Miller,Christian D. Haudenschild,Jacob O. Kitzman,Takuya Nakayama,Yumi Izutsu,Jacques Robert,Joshua D. Fortriede,Kevin A. Burns,Vaneet Lotay,Kamran Karimi,Yuuri Yasuoka,Darwin S. Dichmann,Martin F. Flajnik,Douglas W. Houston,Jay Shendure,Louis DuPasquier,Peter D. Vize,Aaron M. Zorn,Michihiko Ito,Edward M. Marcotte,John B. Wallingford,Yuzuru Ito,Makoto Asashima,Naoto Ueno,Naoto Ueno,Yoichi Matsuda,Gert Jan C. Veenstra,Asao Fujiyama,Asao Fujiyama,Asao Fujiyama,Richard M. Harland,Masanori Taira,Daniel S. Rokhsar,Daniel S. Rokhsar,Daniel S. Rokhsar +80 more
TL;DR: The Xenopus laevis genome is sequenced and it is estimated that the two diploid progenitor species diverged around 34 million years ago and combined to form an allotetraploid around 17–18 Ma, where more than 56% of all genes were retained in two homoeologous copies.
Journal ArticleDOI
Daughters against dpp modulates dpp organizing activity in Drosophila wing development
Kazuhide Tsuneizumi,Takuya Nakayama,Takuya Nakayama,Yuko Kamoshida,Thomas B. Kornberg,Thomas B. Kornberg,Jan L. Christian,Jan L. Christian,Tetsuya Tabata +8 more
TL;DR: It is concluded that the pattern-organizing mechanism governed by Dpp involves a negative-feedback circuit in which Dpp induces expression of its own antagonist, Dad, which appears to be conserved in vertebrate development.
Journal ArticleDOI
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis.
Takuya Nakayama,Margaret B. Fish,Marilyn Fisher,Jamina Oomen-Hajagos,Gerald H. Thomsen,Robert M. Grainger +5 more
TL;DR: A standardized protocol for genome editing using the recently developed CRISPR/Cas system provides a powerful new reverse genetics tool for Xenopus researchers.
Journal ArticleDOI
A protein that binds to a cis-acting element of wheat histone genes has a leucine zipper motif
Tetsuya Tabata,Hisabumi Takase,Shinobu Takayama,Koji Mikami,Atsunori Nakatsuka,Takefumi Kawata,Takuya Nakayama,Masaki Iwabuchi +7 more
TL;DR: The structure and function of transcription factors of higher plants was studied by isolating cDNA clones encoding a wheat sequence-specific DNA binding protein, which indicates that HBP-1 contains the leucine zipper motif, which represents a characteristic property of several eukaryotic transcription factors.