T
Theo Heller
Researcher at National Institutes of Health
Publications - 277
Citations - 19934
Theo Heller is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 55, co-authored 230 publications receiving 16638 citations.
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Journal ArticleDOI
Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C
Yaron Rotman,Mazen Noureddin,Jordan J. Feld,Jeremie Guedj,Jeremie Guedj,Jeremie Guedj,Michael Witthaus,Hwalih Han,Yoon J. Park,Su-Hyung Park,Theo Heller,Marc G. Ghany,Edward Doo,Christopher Koh,Adil A. Abdalla,Naveen Gara,Souvik Sarkar,Emmanuel Thomas,Golo Ahlenstiel,Birgit Edlich,Rachel Titerence,Leah Hogdal,Barbara Rehermann,Harel Dahari,Harel Dahari,Harel Dahari,Alan S. Perelson,Jay H. Hoofnagle,T. Jake Liang +28 more
TL;DR: Ribavirin is a weak antiviral but its clinical effect seems to be mediated by a separate, indirect mechanism, which may act to reset IFN-responsiveness in HCV-infected liver.
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Complications of percutaneous liver biopsy with Klatskin needles: a 36‐year single‐centre experience
Varun Takyar,Ohad Etzion,Theo Heller,David E. Kleiner,Yaron Rotman,Marc G. Ghany,Nancy Fryzek,V. H. Williams,Elenita Rivera,Sungyoung Auh,T. J. Liang,Jay H. Hoofnagle,Christopher Koh +12 more
TL;DR: Liver biopsy is the gold standard in evaluating liver diseases but is susceptible to complications and safety data on aspiration needle biopsies remain limited.
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Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling
Jeremie Guedj,Jeremie Guedj,Jeremie Guedj,Yaron Rotman,Scott J. Cotler,Christopher Koh,Peter Schmid,Jeffrey H. Albrecht,V. Haynes-Williams,T. Jake Liang,Jay H. Hoofnagle,Theo Heller,Harel Dahari +12 more
TL;DR: In this paper, a mathematical model was developed and fitted to frequent hepatitis delta virus (HDV) and hepatitis B surface antigen (HBsAg) kinetic data from 10 patients during the first 28 weeks of pegylated-interferon-α2a (peg-IFN) therapy.
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Lymphocyte-driven regional immunopathology in pneumonitis caused by impaired central immune tolerance
Elise M. N. Ferré,Timothy J. Break,Peter D. Burbelo,Michael Allgäuer,David E. Kleiner,Dakai Jin,Ziyue Xu,Les R. Folio,Daniel J. Mollura,Muthulekha Swamydas,Wenjuan Gu,Sally Hunsberger,Chyi-Chia Richard Lee,Anamaria Bondici,Kevin W. Hoffman,Jean K. Lim,Kerry Dobbs,Julie E. Niemela,Thomas A. Fleisher,Amy P. Hsu,Laquita N. Snow,Dirk Darnell,Samar Ojaimi,Megan A. Cooper,Martin Bozzola,Gary Kleiner,Juan C. Martinez,Robin R. Deterding,Douglas B. Kuhns,Theo Heller,Karen K. Winer,Arun Rajan,Steven M. Holland,Luigi D. Notarangelo,Kevin P. Fennelly,Kenneth N. Olivier,Michail S. Lionakis +36 more
TL;DR: Pneumonitis was found in >40% of patients, presented early in life, was misdiagnosed despite chronic respiratory symptoms and accompanying radiographic and pulmonary function abnormalities, and caused hypoxemic respiratory failure and death.
Journal ArticleDOI
Gastrointestinal Features of Chronic Granulomatous Disease Found During Endoscopy
Sajneet Khangura,Sajneet Khangura,Natasha Kamal,Nancy Ho,Martha Quezado,Xiongce Zhao,Beatriz E. Marciano,Jennifer Simpson,Christa S. Zerbe,Gulbu Uzel,Michael D. Yao,Suk See DeRavin,Colleen Hadigan,Douglas B. Kuhns,John I. Gallin,Harry L. Malech,Steven M. Holland,Theo Heller +17 more
TL;DR: Based on an analysis of clinical and endoscopic data from 78 patients, CGD-inflammatory bowel disease is a distinct entity, primarily involving the anus and rectum, with skip lesions in the remaining bowel.