J
Jeremie Guedj
Researcher at University of Paris
Publications - 161
Citations - 5427
Jeremie Guedj is an academic researcher from University of Paris. The author has contributed to research in topics: Viral load & Medicine. The author has an hindex of 35, co-authored 133 publications receiving 3863 citations. Previous affiliations of Jeremie Guedj include Claude Bernard University Lyon 1 & Bar-Ilan University.
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Journal ArticleDOI
Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea.
Daouda Sissoko,Cédric Laouénan,Elin Folkesson,Abdoul-Bing M’Lebing,Abdoul-Habib Beavogui,Sylvain Baize,Sylvain Baize,Alseny-Modet Camara,Piet Maes,Susan Shepherd,Christine Danel,Sara Carazo,Mamoudou N. Conde,Jean-Luc Gala,Géraldine Colin,Hélène Savini,Joseph Akoi Bore,Frédéric Le Marcis,Fara Raymond Koundouno,Frédéric Petitjean,Marie-Claire Lamah,Sandra Diederich,Alexis Tounkara,Geertrui Poelart,Emmanuel Berbain,Jean-Michel Dindart,Sophie Duraffour,Annabelle Lefevre,Tamba Leno,Olivier Peyrouset,Leonid M. Irenge,N’Famara Bangoura,Romain Palich,Julia Hinzmann,Annette Kraus,Thierno Sadou Barry,Sakoba Berette,André Bongono,Mohamed Seto Camara,Valérie Chanfreau Munoz,Lanciné Doumbouya,Souley Harouna,Patient Mumbere Kighoma,Fara Roger Koundouno,Réné Lolamou,Cécé Moriba Loua,Vincent Massala,Kinda Moumouni,Célia Provost,Nenefing Samake,Conde Sekou,Abdoulaye Soumah,Isabelle Arnould,Michel Saa Komano,Lina Gustin,Carlotta Berutto,Diarra Camara,Fodé Saydou Camara,Joliene Colpaert,Léontine Delamou,Lena Jansson,Etienne Kourouma,Maurice Loua,Kristian Nødtvedt Malme,Emma Manfrin,André Maomou,Adele Milinouno,Sien Ombelet,Aboubacar Youla Sidiboun,Isabelle Verreckt,Pauline Yombouno,Anne Bocquin,Caroline Carbonnelle,Thierry Carmoi,Pierre Frange,Stéphane Mély,Vinh-Kim Nguyen,Delphine Pannetier,Anne-Marie Taburet,Jean-Marc Treluyer,Jacques Seraphin Kolié,Raoul Moh,Minerva Cervantes Gonzalez,Eeva Kuisma,Britta Liedigk,Didier Ngabo,Martin Rudolf,Ruth Thom,Romy Kerber,Martin Gabriel,Antonino Di Caro,Roman Wölfel,Jamal Badir,Mostafa Bentahir,Yann Deccache,Catherine Dumont,Jean-François Durant,Karim El Bakkouri,Marie Gasasira Uwamahoro,Benjamin Smits,Nora Toufik,Stéphane Van Cauwenberghe,Khaled Ezzedine,Eric D'Ortenzio,Louis Pizarro,Aurélie Etienne,Jeremie Guedj,Alexandra Fizet,Alexandra Fizet,Eric Barte de Sainte Fare,Bernadette Murgue,Tuan Tran-Minh,Christophe Rapp,Pascal Piguet,Marc Poncin,Bertrand Draguez,Thierry Allaford Duverger,Solenne Barbe,Guillaume Baret,Isabelle Defourny,Miles W. Carroll,Miles W. Carroll,Hervé Raoul,Augustin Augier,Serge Eholié,Yazdan Yazdanpanah,Claire Levy-Marchal,Annick Antierrens,Michel Van Herp,Stephan Günther,Xavier de Lamballerie,Sakoba Keita,Xavier Anglaret,Denis Malvy +133 more
TL;DR: The objectives of the trial were to test the feasibility and acceptability of an emergency trial in the context of a large Ebola outbreak, and to collect data on the safety and effectiveness of favipiravir in reducing mortality and viral load in patients with EVD.
Journal ArticleDOI
Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
Jeremie Guedj,Harel Dahari,Harel Dahari,Harel Dahari,Libin Rong,Natasha Sansone,Natasha Sansone,Richard E. Nettles,Scott J. Cotler,Thomas J. Layden,Susan L. Uprichard,Susan L. Uprichard,Alan S. Perelson +12 more
TL;DR: It is shown that understanding the effects of daclatasvir in vivo requires a multiscale model that incorporates drug effects on the HCV intracellular lifecycle, and this approach is validated with in vitro HCV infection experiments and yields a more precise estimate of the serum HCV half-life.
Journal ArticleDOI
Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
Pauline Maisonnasse,Jeremie Guedj,Vanessa Contreras,Sylvie Behillil,Sylvie Behillil,Caroline Solas,Romain Marlin,Thibaut Naninck,Andrés Pizzorno,Julien Lemaitre,Antonio Gonçalves,Nidhal Kahlaoui,Olivier Terrier,Raphael Ho Tsong Fang,Vincent Enouf,Vincent Enouf,Nathalie Dereuddre-Bosquet,Angela Brisebarre,Angela Brisebarre,Franck Touret,Catherine Chapon,Bruno Hoen,Bruno Lina,Manuel Rosa Calatrava,Sylvie van der Werf,Sylvie van der Werf,Xavier de Lamballerie,Roger Le Grand +27 more
TL;DR: Hydroxychloroquine did not confer protection against SARS-CoV-2 infection or reduce the viral load after infection in macaques; these findings do not support the use of hydroxy chloroquine as an antiviral drug treatment of COVID-19 in humans.
Journal ArticleDOI
Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial.
Florence Ader,M. Bouscambert-Duchamp,Maya Hites,Nathan Peiffer-Smadja,Nathan Peiffer-Smadja,Julien Poissy,Drifa Belhadi,Alpha Diallo,Minh-Patrick Le,Gilles Peytavin,Thérèse Staub,Richard Greil,Jeremie Guedj,José Artur Paiva,Dominique Costagliola,Yazdan Yazdanpanah,Charles Burdet,Alexander Egle,Michael Joannidis,Bernd Lamprecht,Antoine Altdorfer,Leila Belkhir,Vincent Fraipont,Gil Verschelden,Jérôme Aboab,Hafid Ait-Oufella,Claire Andrejak,Pascal Andreu,Laurent Argaud,Firouzé Bani-Sadr,François Bénézit,M. Blot,Elisabeth Botelho-Nevers,Lila Bouadma,Olivier Bouchaud,David Bougon,Kevin Bouiller,Fanny Bounes-Vardon,David Boutoille,Alexandre Boyer,Cédric Bruel,André Cabié,Emmanuel Canet,Charles Cazanave,Cyrille Chabartier,Catherine Chirouze,Raphaël Clere-Jehl,Johan Courjon,Flora Crockett,François Danion,Agathe Delbove,Jean Dellamonica,F. Djossou,Clément Dubost,Alexandre Duvignaud,Olivier Epaulard,Loïc Epelboin,Murielle Fartoukh,Karine Faure,Emmanuel Faure,Tristan Ferry,Cécile Ficko,Samy Figueiredo,Benjamin Gaborit,Rostane Gaci,Amandine Gagneux-Brunon,Sébastien Gallien,Denis Garot,Guillaume Geri,Sébastien Gibot,François Goehringer,Marie Gousseff,Didier Gruson,Yves Hansmann,Olivier Hinschberger,Stéphane Jauréguiberry,Vanessa Jeanmichel,Solen Kernéis,Antoine Kimmoun,Kada Klouche,Marie Lachâtre,Karine Lacombe,Fabrice Laine,Jean-Philippe Lanoix,Odile Launay,Bruno Laviolle,Vincent Le Moing,Jérôme Le Pavec,Yves Le Tulzo,Paul Le Turnier,David Lebeaux,Benjamin Lefevre,Sylvie Leroy,François-Xavier Lescure,Henry Lessire,Benjamin Leveau,Paul Loubet,Alain Makinson,Denis Malvy,Charles-Hugo Marquette,Guillaume Martin-Blondel,Martin Martinot,Julien Mayaux,Armand Mekontso-Dessap,Ferhat Meziani,Jean-Paul Mira,Jean-Michel Molina,Xavier Monnet,Joy Mootien,Bruno Mourvillier,Marlène Murris-Espin,Jean-Christophe Navellou,Saad Nseir,Walid Oulehri,Thomas Perpoint,Gilles Pialoux,Benoit Pilmis,Vincent Piriou,Lionel Piroth,Valérie Pourcher,Jean-Pierre Quenot,François Raffi,Jean Reignier,Matthieu Revest,Jean-Christophe Richard,Béatrice Riu-Poulenc,Céline Robert,Pierre-Alexandre Roger,Claire Roger,Elisabeth Rouveix-Nordon,Yvon Ruch,Nadia Saidani,Naomi Sayre,Eric Senneville,Albert Sotto,Francois Stefan,Charles Tacquard,Nicolas Terzi,Julien Textoris,Guillaume Thiery,Jean-François Timsit,Violaine Tolsma,Jean-Marie Turmel,Florent Valour,Florent Wallet,Guilhem Wattecamps,Yoann Zerbib,Marc Berna,Jean Reuter,Sandra Braz,Joao-Miguel Ferreira Ribeiro,Roberto Roncon-Albuquerque,Alexandre Gaymard,Bruno Lina,Sarah Tubiana,Sandrine Couffin-Cadiergues,Hélène Espérou,Aline Dechanet,Christelle Delmas,Claire Fougerou,Noémie Mercier,Marion Noret,Juliette Saillard,Priyanka Velou +163 more
TL;DR: The DisCoVeRy trial as mentioned in this paper evaluated the clinical efficacy of remdesivir plus standard care compared with standard of care alone in patients admitted to hospital with COVID-19, with indication of oxygen or ventilator support.
Journal ArticleDOI
Quantifying the diversification of hepatitis C virus (HCV) during primary infection: estimates of the in vivo mutation rate.
Ruy M. Ribeiro,Hui Li,Shuyi Wang,Mark B. Stoddard,Gerald H. Learn,Bette T. Korber,Tanmoy Bhattacharya,Jeremie Guedj,Erica H. Parrish,Beatrice H. Hahn,George M. Shaw,Alan S. Perelson +11 more
TL;DR: A new stochastic model of the HCV life cycle is developed and it is found that the accumulation of mutations is surprisingly slow: at 30 days, the viral population on average is still 46% identical to its transmitted viral genome.