Thomas A. Hawkins

TL;DR: Loss-of-function analyses in zebrafish embryos show a key role for Wnt/β-catenin signaling in the expression of myelin genes and in myelin sheath compaction, both in the peripheral and central nervous systems.

TL;DR: A genetic screen that identified 13 mutations, which define 10 genes, disrupting the development of myelinated axons in zebrafish is reported, and phenotypic analyses indicate that the genes affect a wide range of steps in glial development, from fate specification through terminal differentiation.

TL;DR: It is demonstrated that HCNEs conserved between human and zebrafish can be systematically and reliably tested for their regulatory function in multiple stable transgenes in zebra fish, and their genomic reach estimated with confidence using synteny conservation and HCNE density along these loci.

TL;DR: This first report on brain lymphatic endothelial cells in a vertebrate embryo identifies cells with unique features, including the uptake of macromolecules at a single cell level.

TL;DR: The zebrafish slothu45 mutant is characterised, in which the initial steps in sarcomere assembly take place, but thick filaments are absent and filamentous I-Z-I brushes fail to align or adopt correct spacing, and a surprisingly specific developmental role for a single Hsp90 gene in a regulatory pathway controlling late steps in Sarcomere Assembly is revealed.