Cristian Prieto-Garcia

TL;DR: It is reported that the deubiquitylase USP28 stabilizes ∆Np63 and maintains elevated ∆NP63 levels in SCC by counteracting its proteasome‐mediated degradation.

TL;DR: 3Cs multiplexing as mentioned in this paper is a scalable method to generate highly diverse and uniformly distributed combinatorial CRISPR libraries with low distribution skews, and it has been shown that the library distribution skew is critical determinant of its required screening coverage.

TL;DR: In this article, the authors discuss the emerging role of USP28 in cancer and discuss the complexity and mutational landscape of squamous tumors, as well as the genetic alterations and cellular pathways that determine the function of USp28 in squamous cancer.

TL;DR: In this article , the authors demonstrate that loss of PTEN led to altered expression of transcriptional programs which directly regulate therapy resistance, resulting in establishment of radiation resistance, and they show that low concentration of ATM inhibitor is able to synergise with IR to treat PTEN-deficient tumors in genetically well-defined IR resistant lung cancer models.

TL;DR: In this paper , the authors reported the identification of the endothelial cell-enriched long non-coding RNA (lncRNA) PCAT19, which contributes to the proliferative switch and acts as a safeguard for the endothelium.