T
Thomas Grund
Researcher at University of Regensburg
Publications - 9
Citations - 517
Thomas Grund is an academic researcher from University of Regensburg. The author has contributed to research in topics: Neuropeptide S & Neuropeptide. The author has an hindex of 8, co-authored 9 publications receiving 389 citations.
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Journal ArticleDOI
Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study
Trynke R. de Jong,Rohit Menon,Anna Bludau,Thomas Grund,Verena Biermeier,Stefanie M. Klampfl,Benjamin Jurek,Oliver J. Bosch,Juliane Hellhammer,Inga D. Neumann +9 more
TL;DR: The Regensburg Oxytocin Challenge (ROC) test reliably assess the responsiveness of the OXT system to challenges such as "Run" and "Sex" at home or psychosocial stress (TSST) in the laboratory.
Journal ArticleDOI
Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation
Rohit Menon,Thomas Grund,Iulia Zoicas,Ferdinand Althammer,Dominik Fiedler,Verena Biermeier,Oliver J. Bosch,Yuichi Hiraoka,Katsuhiko Nishimori,Marina Eliava,Valery Grinevich,Inga D. Neumann +11 more
TL;DR: This work investigates the capacity of brain OXT receptor (OXTR) signaling in the lateral septum (LS) to prevent social fear expression in female mice using the social-fear-conditioning paradigm, and shows that lactating mice did not express fear 24 hr after social fear conditioning.
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Oxytocin Stimulates Extracellular Ca 2+ Influx Through TRPV2 Channels in Hypothalamic Neurons to Exert Its Anxiolytic Effects
TL;DR: Functional and pharmacological analyses identified TRPV2 as a mediator of anxiolytic effects of OXT, conveying the OXT signal to MEK1/2 via modulation of intracellular Ca2+.
Journal ArticleDOI
Selective Breeding for High Anxiety Introduces a Synonymous SNP That Increases Neuropeptide S Receptor Activity
David A. Slattery,Roshan R. Naik,Thomas Grund,Yi-Chun Yen,Simone B. Sartori,Andrea M. Füchsl,Beate C. Finger,Betina Elfving,Uwe Nordemann,Remo Guerrini,Girolamo Calo,Gregers Wegener,Aleksander A. Mathé,Nicolas Singewald,L. Czibere,Rainer Landgraf,Inga D. Neumann +16 more
TL;DR: Results suggest that alterations in the NPS system, conserved across rodents and humans, contribute to innate anxiety and fear, and that HAB rodents are particularly suited to resolve the apparent discrepancy between the preclinical and clinical findings to date.
Journal ArticleDOI
Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis.
Thomas Grund,Stéphanie Goyon,Yuting Li,Marina Eliava,Haikun Liu,Alexandre Charlet,Alexandre Charlet,Valery Grinevich,Inga D. Neumann +8 more
TL;DR: The results indicate a significant role of the OXT system in mediating the effects of NPS on anxiety, and fill an important gap in the understanding of brain neuropeptide interactions in the context of regulation of emotional behavior within the hypothalamus.