T
Thomas Langer
Researcher at Max Planck Society
Publications - 253
Citations - 26029
Thomas Langer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Mitochondrion & mitochondrial fusion. The author has an hindex of 82, co-authored 222 publications receiving 23219 citations. Previous affiliations of Thomas Langer include Heidelberg University & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
Weiyi Chen,Hendrik Nolte,Paul Klemm,Sinika Henschke,Lukas Steuernagel,Tamara Sotelo-Hitschfeld,Claudia M. Wunderlich,Thomas Langer,Natalia L. Kononenko,Patrick Giavalisco,Jens C. Brüning +10 more
TL;DR: The authors found that fasting in mice activates autophagy in the liver paralleled by activation of hypothalamic AgRP neurons, which represents a key regulator of aging and metabolism in sensing energy deprivation.
Journal ArticleDOI
A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis.
Esra Peker,Konstantin Weiss,Jiyao Song,Christine Zarges,Sarah Gerlich,Volker Boehm,Aleksandra Trifunovic,Thomas Langer,Niels H. Gehring,Thomas Becker,Jan Riemer +10 more
TL;DR: In this paper , the authors found that the complex I assembly factor NDUFAF8 follows a two-step import pathway linking IMS and matrix import systems, which allows exposure to the IMS disulfide relay.
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Backbone NMR assignment of the C-terminal haemopexin-like domain (HPLD) of human matrix metalloproteinase MMP-13.
Doris M. Jacobs,Susanne Grimme,Bettina Elshorst,Barbara Pescatore,Martin Vogtherr,Marco Betz,Ulrich Schieborr,Thomas Langer,Krishna Saxena,Harald Schwalbe,Klaus M. Fiebig +10 more
TL;DR: Electronic supplementary material Electronic supplementary material is available for this article at http://dx.doi.org/10.1007/s10858-005-0463-7 and accessible for authorised users.
Journal ArticleDOI
Backbone 1H, 13C, and 15N Chemical Shift Assignments for the peptidyl-prolyl cis-trans isomerase Pin1
Doris M. Jacobs,Krishna Saxena,Susanne Grimme,Martin Vogtherr,Barbara Pescatore,Thomas Langer,Bettina Elshorst,Klaus M. Fiebig +7 more
Posted ContentDOI
High-throughput phenotypic screen for genetic modifiers in patient-derived OPA1 mutant fibroblasts identifies PGS1 as a functional suppressor of mitochondrial fragmentation
E. Cretin,P. Thomas,Elodie Vimont,Takashi Tatsuta,Thomas Langer,Thomas Langer,Patrick Yu-Wai-Man,Pascal Reynier,Timothy Wai,Timothy Wai +9 more
TL;DR: In this article, a high-throughput imaging pipeline using supervised machine learning (ML) was used to perform unbiased, quantitative mitochondrial morphology analysis that was coupled with a bespoke siRNA library targeting the entire known mitochondrial proteome (1531 genes), providing a detailed phenotype screening of human fibroblasts.