T
Thomas Langer
Researcher at Max Planck Society
Publications - 253
Citations - 26029
Thomas Langer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Mitochondrion & mitochondrial fusion. The author has an hindex of 82, co-authored 222 publications receiving 23219 citations. Previous affiliations of Thomas Langer include Heidelberg University & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion
Fabian Anton,Julia M. Fres,Astrid Schauss,Benoît Pinson,Gerrit J. K. Praefcke,Thomas Langer,Mafalda Escobar-Henriques,Mafalda Escobar-Henriques +7 more
TL;DR: It is suggested that protein clearance confers a non-cycling mechanism to mitofusins, which is distinct from other cellular membrane fusion events.
Journal ArticleDOI
m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration
Maria Patron,Maria Patron,Hans-Georg Sprenger,Hans-Georg Sprenger,Thomas Langer,Thomas Langer +5 more
TL;DR: The relationship between the m-AAA protease and mitochondrial calcium homeostasis and its relevance for neurodegeneration is discussed and a novel mouse model lacking MCU specifically in Purkinje cells is described.
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Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development
Sachin Supale,Fabrizio Thorel,Carsten Merkwirth,Asllan Gjinovci,Pedro Luis Herrera,Luca Scorrano,Paolo Meda,Thomas Langer,Pierre Maechler +8 more
TL;DR: The data demonstrate that Phb2 is essential for metabolic activation of mitochondria and, as a consequence, for function and survival of β-cells and the expression of prohibitins in human and rodent islets is documented.
Journal ArticleDOI
Regulated protein degradation in mitochondria.
Thomas Langer,Walter Neupert +1 more
TL;DR: The mitochondrial inner membrane harbors two ATP-dependent metallopeptidases, them- and thei-AAA protease, which expose their catalytic sites to opposite membrane surfaces and cooperate in the degradation of inner membrane proteins.
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Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.
Claus Brandt,Claus Brandt,Hendrik Nolte,Sinika Henschke,Sinika Henschke,Linda Engström Ruud,Linda Engström Ruud,Motoharu Awazawa,Motoharu Awazawa,Donald A. Morgan,Paula Gabel,Paula Gabel,Hans-Georg Sprenger,Martin E. Hess,Martin E. Hess,Stefan Günther,Thomas Langer,Thomas Langer,Kamal Rahmouni,Henning Fenselau,Henning Fenselau,Marcus Krüger,Jens C. Brüning +22 more
TL;DR: It is demonstrated that sensory food perception coordinately primes postprandial liver ER adaption through a melanocortin-SNA-mTOR-Xbp1s axis.