T
Thomas Langer
Researcher at Max Planck Society
Publications - 253
Citations - 26029
Thomas Langer is an academic researcher from Max Planck Society. The author has contributed to research in topics: Mitochondrion & mitochondrial fusion. The author has an hindex of 82, co-authored 222 publications receiving 23219 citations. Previous affiliations of Thomas Langer include Heidelberg University & Ludwig Maximilian University of Munich.
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The chaperonin-related protein Tcm62p ensures mitochondrial gene expresssion under heat stress
TL;DR: It is demonstrated that crucial functions of Tcm62p under heat stress ensures mitochondrial gene expression at elevated temperatures and prevents heat‐aggregation of the ribosomal subunit Var1p.
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Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy
Talha Rashid,Ivan Nemazanyy,Cecilia Paolini,Takashi Tatsuta,Paul Crespin,Paul Crespin,Delphine de Villeneuve,Delphine de Villeneuve,Susanne Brodesser,Paule Bénit,Pierre Rustin,Martin A. Baraibar,Onnik Agbulut,Anne Olivier,Feliciano Protasi,Thomas Langer,Roman Chrast,Pascale de Lonlay,Pascale de Lonlay,Helene de Foucauld,Bert Blaauw,Mario Pende,Mario Pende +22 more
TL;DR: It is shown that Lipin1 deficiency in mouse skeletal muscles is sufficient to trigger myopathy, and pharmacological treatments with the chaperone TUDCA and the fatty acid oxidation activator bezafibrate improve muscle histology and strength of lipin1 mutants.
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NMR backbone assignment of the mitogen-activated protein (MAP) kinase p38
Martin Vogtherr,Krishna Saxena,Susanne Grimme,Marco Betz,Ulrich Schieborr,Barbara Pescatore,Thomas Langer,Harald Schwalbe +7 more
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ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Frank Richter,Sven Dennerlein,Miroslav Nikolov,Daniel C. Jans,Daniel C. Jans,Nataliia Naumenko,Abhishek Aich,Thomas MacVicar,Andreas Linden,Andreas Linden,Stefan Jakobs,Stefan Jakobs,Henning Urlaub,Henning Urlaub,Thomas Langer,Peter Rehling,Peter Rehling +16 more
TL;DR: This work defines the constituents of the human TIM23 complex using mass spectrometry and identified ROMO1 as a new translocase constituent with an exceptionally short half-life and establishes an unexpected link between mitochondrial protein import and inner membrane protein quality control.
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Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement.
Martin Graef,Thomas Langer +1 more
TL;DR: An essential function of the central pore loop for the ATP-dependent translocation of membrane proteins into a proteolytic cavity formed by AAA proteases is suggested.