P
Paul Klemm
Researcher at Max Planck Society
Publications - 27
Citations - 487
Paul Klemm is an academic researcher from Max Planck Society. The author has contributed to research in topics: Neuron & Visual analytics. The author has an hindex of 10, co-authored 21 publications receiving 284 citations. Previous affiliations of Paul Klemm include Otto-von-Guericke University Magdeburg & University of Marburg.
Papers
More filters
Journal ArticleDOI
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Elena Schmidt,Elena Schmidt,Ines Dhaouadi,Ines Dhaouadi,Isabella Gaziano,Isabella Gaziano,Matteo Oliverio,Matteo Oliverio,Paul Klemm,Paul Klemm,Motoharu Awazawa,Motoharu Awazawa,Gerfried Mitterer,Eduardo Fernandez-Rebollo,Eduardo Fernandez-Rebollo,Marta Pradas-Juni,Marta Pradas-Juni,Marta Pradas-Juni,Wolfgang Wagner,Philipp Hammerschmidt,Philipp Hammerschmidt,Rute Loureiro,Rute Loureiro,Rute Loureiro,Christoph A. Kiefer,Nils R. Hansmeier,Nils R. Hansmeier,Sajjad Khani,Sajjad Khani,Matteo Bergami,Markus Heine,Evgenia Ntini,Peter Frommolt,Peter Zentis,Ulf Andersson Ørom,Jörg Heeren,Matthias Blüher,Martin Bilban,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld,Jan-Wilhelm Kornfeld +40 more
TL;DR: A maternally expressed, imprinted lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure is identified and it is demonstrated that H19 recruits PEG-inactivating H19-MBD1 complexes and acts as BAT-selective PEG gatekeeper.
Journal ArticleDOI
Interactive Visual Analysis of Image-Centric Cohort Study Data.
TL;DR: An Interactive Visual Analysis approach that enables epidemiologists to rapidly investigate the entire data pool for hypothesis validation and generation is proposed and demonstrated by validating and generating hypotheses related to lower back pain as a qualitative evaluation.
Journal ArticleDOI
PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding
Alexander Jais,Alexander Jais,Lars Paeger,Tamara Sotelo-Hitschfeld,Tamara Sotelo-Hitschfeld,Stephan Bremser,Melanie Prinzensteiner,Melanie Prinzensteiner,Paul Klemm,Paul Klemm,Vasyl Mykytiuk,Pia J.M. Widdershooven,Pia J.M. Widdershooven,Anna Juliane Vesting,Anna Juliane Vesting,Katarzyna Grzelka,Marielle Minére,Anna Lena Cremer,Jie Xu,Tatiana Korotkova,Bradford B. Lowell,Bradford B. Lowell,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer,Heiko Backes,Henning Fenselau,F. Thomas Wunderlich,F. Thomas Wunderlich,Peter Kloppenburg,Jens C. Brüning,Jens C. Brüning +30 more
TL;DR: Calorie-rich diets induce hyperphagia and promote obesity, although the underlying mechanisms remain poorly defined, and PNOCARC neurons are characterized as a novel ARC neuron population activated upon palatable food consumption to promote hyperphags.
Journal ArticleDOI
3D Regression Heat Map Analysis of Population Study Data
Paul Klemm,Kai Lawonn,Sylvia Glaßer,Uli Niemann,Katrin Hegenscheid,Henry Völzke,Bernhard Preim +6 more
TL;DR: A visual overview of epidemiological data that allows for the first time an interactive regression-based analysis of large feature sets with respect to a disease and new hypotheses about relations between breast density and breast lesions with breast cancer are derived.
Journal ArticleDOI
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting
Nasim Biglari,Nasim Biglari,Isabella Gaziano,Isabella Gaziano,Jonas Schumacher,Jonas Schumacher,Jan Radermacher,Lars Paeger,Paul Klemm,Paul Klemm,Weiyi Chen,Weiyi Chen,Svenja Corneliussen,Claudia M. Wunderlich,Claudia M. Wunderlich,Michael Sué,Stefan Vollmar,Tim Klöckener,Tim Klöckener,Tamara Sotelo-Hitschfeld,Tamara Sotelo-Hitschfeld,Amin Abbasloo,Frank Edenhofer,Frank Reimann,Fiona M. Gribble,Henning Fenselau,Henning Fenselau,Peter Kloppenburg,Frank Thomas Wunderlich,Frank Thomas Wunderlich,Jens C. Brüning +30 more
TL;DR: In this article, intersectional Cre/Dre-dependent recombination allowed for successful labeling, translational profiling and functional characterization of distinct POMC neurons expressing the leptin receptor (Lepr) and glucagon like peptide 1 receptor (Glp1r).