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Thomas Owley
Researcher at University of Illinois at Chicago
Publications - 20
Citations - 3399
Thomas Owley is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Autism & Escitalopram. The author has an hindex of 14, co-authored 20 publications receiving 3225 citations. Previous affiliations of Thomas Owley include Rush University Medical Center & University of Chicago.
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Journal ArticleDOI
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Joseph T. Glessner,Kai Wang,Guiqing Cai,Olena Korvatska,Cecilia E. Kim,Shawn Wood,Haitao Zhang,Annette Estes,Camille W. Brune,Jonathan P. Bradfield,Marcin Imielinski,Edward C. Frackelton,Jennifer Reichert,Emily L. Crawford,Jeffrey Munson,Patrick M. A. Sleiman,Rosetta M. Chiavacci,Kiran Annaiah,Kelly A. Thomas,Cuiping Hou,Wendy Glaberson,James H. Flory,Frederick G. Otieno,Maria Garris,Latha Soorya,Lambertus Klei,Joseph Piven,Kacie J. Meyer,Evdokia Anagnostou,Takeshi Sakurai,Rachel M. Game,Danielle S. Rudd,Danielle Zurawiecki,Christopher J. McDougle,Lea K. Davis,Judith Miller,David J. Posey,Shana M. Michaels,Alexander Kolevzon,Jeremy M. Silverman,Raphael Bernier,Susan E. Levy,Robert T. Schultz,Geraldine Dawson,Thomas Owley,William M. McMahon,Thomas H. Wassink,John A. Sweeney,John I. Nurnberger,Hilary Coon,James S. Sutcliffe,Nancy J. Minshew,Struan F.A. Grant,Maja Bucan,Edwin H. Cook,Joseph D. Buxbaum,Bernie Devlin,Gerard D. Schellenberg,Hakon Hakonarson +58 more
TL;DR: Several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls, and duplications 55 kilobases upstream of complementary DNA AK123120 indicate that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.
Journal ArticleDOI
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Kai Wang,Haitao Zhang,Deqiong Ma,Maja Bucan,Joseph T. Glessner,Brett S. Abrahams,Daria Salyakina,Marcin Imielinski,Jonathan P. Bradfield,Patrick M. A. Sleiman,Cecilia E. Kim,Cuiping Hou,Edward C. Frackelton,Rosetta M. Chiavacci,Nagahide Takahashi,Takeshi Sakurai,Eric F. Rappaport,Clara Lajonchere,Jeffrey Munson,Annette Estes,Olena Korvatska,Joseph Piven,Lisa I. Sonnenblick,Ana I. Alvarez Retuerto,Edward I. Herman,Hongmei Dong,Ted Hutman,Marian Sigman,Sally J Ozonoff,Ami Klin,Thomas Owley,John A. Sweeney,Camille W. Brune,Rita M. Cantor,Raphael Bernier,John R. Gilbert,Michael L. Cuccaro,William M. McMahon,Judith Miller,Matthew W. State,Thomas H. Wassink,Hilary Coon,Susan E. Levy,Robert T. Schultz,John I. Nurnberger,Jonathan L. Haines,James S. Sutcliffe,Edwin H. Cook,Nancy J. Minshew,Joseph D. Buxbaum,Geraldine Dawson,Struan F.A. Grant,Daniel H. Geschwind,Margaret A. Pericak-Vance,Gerard D. Schellenberg,Hakon Hakonarson +55 more
TL;DR: The results implicate neuronal cell-adhesion molecules in the pathogenesis of ASDs, and represent, to the authors' knowledge, the first demonstration of genome-wide significant association of common variants with susceptibility to ASDs.
Journal ArticleDOI
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes
Maja Bucan,Brett S. Abrahams,Kai Wang,Joseph T. Glessner,Edward I. Herman,Lisa I. Sonnenblick,Ana I. Alvarez Retuerto,Marcin Imielinski,Dexter Hadley,Jonathan P. Bradfield,Cecilia Kim,Nicole B. Gidaya,Ingrid E. Lindquist,Ted Hutman,Marian Sigman,Vlad Kustanovich,Clara Lajonchere,Andrew B. Singleton,Junhyong Kim,Thomas H. Wassink,William M. McMahon,Thomas Owley,John A. Sweeney,Hilary Coon,John I. Nurnberger,Mingyao Li,Rita M. Cantor,Nancy J. Minshew,James S. Sutcliffe,Edwin H. Cook,Geraldine Dawson,Joseph D. Buxbaum,Struan F.A. Grant,Gerard D. Schellenberg,Daniel H. Geschwind,Hakon Hakonarson +35 more
TL;DR: To pinpoint genes likely to contribute to ASD etiology, high density genotyping was performed in 912 multiplex families from the Autism Genetics Resource Exchange collection and contrasted results to those obtained for 1,488 healthy controls.
Journal ArticleDOI
Utility of the Gilliam Autism Rating Scale in research and clinical populations.
Mikle South,Brenda J. Williams,William M. McMahon,Thomas Owley,Pauline A. Filipek,Elisa S. Shernoff,Christine Corsello,Janet E. Lainhart,Rebecca Landa,Sally J Ozonoff +9 more
TL;DR: The validity of the GARS when used with a sample of 119 children with strict DSM-IV diagnoses of autism, ascertained from both clinical and research settings is examined.
Journal ArticleDOI
Multisite, double-blind, placebo-controlled trial of porcine secretin in autism.
Thomas Owley,William M. McMahon,Edwin H. Cook,Tracy M. Laulhere,Mikle South,Lee Z. Mays,Elisa S. Shernoff,Janet E. Lainhart,Charlotte Modahl,Christina Corsello,Sally J Ozonoff,Susan Risi,Catherine Lord,Bennett L. Leventhal,Pauline A. Filipek +14 more
TL;DR: There was no evidence for efficacy of secretin in this randomized, placebo-controlled, double-blind trial of intravenous porcine secretin for the treatment of autistic disorder.