M
Maria Garris
Researcher at Children's Hospital of Philadelphia
Publications - 17
Citations - 3924
Maria Garris is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 16, co-authored 17 publications receiving 3687 citations. Previous affiliations of Maria Garris include University of Pennsylvania.
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Journal ArticleDOI
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Joseph T. Glessner,Kai Wang,Guiqing Cai,Olena Korvatska,Cecilia E. Kim,Shawn Wood,Haitao Zhang,Annette Estes,Camille W. Brune,Jonathan P. Bradfield,Marcin Imielinski,Edward C. Frackelton,Jennifer Reichert,Emily L. Crawford,Jeffrey Munson,Patrick M. A. Sleiman,Rosetta M. Chiavacci,Kiran Annaiah,Kelly A. Thomas,Cuiping Hou,Wendy Glaberson,James H. Flory,Frederick G. Otieno,Maria Garris,Latha Soorya,Lambertus Klei,Joseph Piven,Kacie J. Meyer,Evdokia Anagnostou,Takeshi Sakurai,Rachel M. Game,Danielle S. Rudd,Danielle Zurawiecki,Christopher J. McDougle,Lea K. Davis,Judith Miller,David J. Posey,Shana M. Michaels,Alexander Kolevzon,Jeremy M. Silverman,Raphael Bernier,Susan E. Levy,Robert T. Schultz,Geraldine Dawson,Thomas Owley,William M. McMahon,Thomas H. Wassink,John A. Sweeney,John I. Nurnberger,Hilary Coon,James S. Sutcliffe,Nancy J. Minshew,Struan F.A. Grant,Maja Bucan,Edwin H. Cook,Joseph D. Buxbaum,Bernie Devlin,Gerard D. Schellenberg,Hakon Hakonarson +58 more
TL;DR: Several new susceptibility genes encoding neuronal cell-adhesion molecules, including NLGN1 and ASTN2, were enriched with CNVs in ASD cases compared to controls, and duplications 55 kilobases upstream of complementary DNA AK123120 indicate that these two important gene networks expressed within the central nervous system may contribute to the genetic susceptibility of ASD.
Journal ArticleDOI
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
Josephine Elia,Joseph T. Glessner,Kai Wang,Nagahide Takahashi,Corina Shtir,Dexter Hadley,Patrick M. A. Sleiman,Haitao Zhang,Cecilia E. Kim,Reid J. Robison,Gholson J. Lyon,James H. Flory,Jonathan P. Bradfield,Marcin Imielinski,Cuiping Hou,Edward C. Frackelton,Rosetta M. Chiavacci,Takeshi Sakurai,Cara R. Rabin,Frank A. Middleton,Kelly A. Thomas,Maria Garris,Frank D. Mentch,Christine M. Freitag,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,Alexandre A. Todorov,Andreas Reif,Aribert Rothenberger,Barbara Franke,Eric Mick,Herbert Roeyers,Jan K. Buitelaar,Klaus-Peter Lesch,Tobias Banaschewski,Richard P. Ebstein,Fernando Mulas,Robert D. Oades,Joseph A. Sergeant,Edmund J.S. Sonuga-Barke,Edmund J.S. Sonuga-Barke,Edmund J.S. Sonuga-Barke,Tobias J. Renner,Marcel Romanos,Jasmin Romanos,Andreas Warnke,Susanne Walitza,Susanne Walitza,Jobst Meyer,Haukur Palmason,Christiane Seitz,Sandra K. Loo,Susan L. Smalley,Joseph Biederman,Lindsey Kent,Philip Asherson,Richard Anney,J. William Gaynor,Philip Shaw,Marcella Devoto,Peter White,Struan F.A. Grant,Struan F.A. Grant,Joseph D. Buxbaum,Judith L. Rapoport,Nigel Williams,Stanley F. Nelson,Stephen V. Faraone,Hakon Hakonarson +69 more
TL;DR: A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ∼10% of the cases, and rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts were identified.
Journal ArticleDOI
Variants of DENND1B Associated with Asthma in Children
Patrick M. A. Sleiman,James H. Flory,Marcin Imielinski,Jonathan P. Bradfield,Kiran Annaiah,Saffron A.G. Willis-Owen,Kai Wang,Nicholas Rafaels,Sven Michel,Klaus Bønnelykke,Haitao Zhang,Cecilia E. Kim,Edward C. Frackelton,Joseph T. Glessner,Cuiping Hou,F. George Otieno,Erin Santa,Kelly A. Thomas,Ryan M. Smith,Wendy Glaberson,Maria Garris,Rosetta M. Chiavacci,Terri H. Beaty,Ingo Ruczinski,Jordan M. Orange,Julian L. Allen,Jonathan M. Spergel,Robert W. Grundmeier,Rasika A. Mathias,Jason D. Christie,Erika von Mutius,William O.C.M. Cookson,Michael Kabesch,Miriam F. Moffatt,Michael M. Grunstein,Kathleen C. Barnes,Marcella Devoto,Mark R. Magnusson,Hongzhe Li,Struan F.A. Grant,Hans Bisgaard,Hakon Hakonarson +41 more
TL;DR: A locus containing DENND1B on chromosome 1q31.3 that is associated with susceptibility to asthma is identified and predicted to interact with the tumor necrosis factor α receptor.
Journal ArticleDOI
Integrative genomics identifies LMO1 as a neuroblastoma oncogene
Kai Wang,Kai Wang,Sharon J. Diskin,Haitao Zhang,Edward F. Attiyeh,Cynthia Winter,Cuiping Hou,Robert W. Schnepp,Maura Diamond,Kristopher R. Bosse,Patrick A. Mayes,Joseph T. Glessner,Cecilia Kim,Edward C. Frackelton,Maria Garris,Qun Wang,Wendy Glaberson,Rosetta M. Chiavacci,Le Nguyen,Le Nguyen,Jayanti Jagannathan,Norihisa Saeki,Hiroki Sasaki,Struan F.A. Grant,Struan F.A. Grant,Achille Iolascon,Yael P. Mosse,Yael P. Mosse,Kristina A. Cole,Kristina A. Cole,Hongzhe Li,Marcella Devoto,Patrick McGrady,Wendy B. London,Mario Capasso,Nazneen Rahman,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +39 more
TL;DR: Data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression.
Journal ArticleDOI
Common variations in BARD1 influence susceptibility to high-risk neuroblastoma
Mario Capasso,Marcella Devoto,Cuiping Hou,Shahab Asgharzadeh,Joseph T. Glessner,Edward F. Attiyeh,Edward F. Attiyeh,Yael P. Mosse,Yael P. Mosse,Cecilia Kim,Sharon J. Diskin,Sharon J. Diskin,Kristina A. Cole,Kristina A. Cole,Kristopher R. Bosse,Kristopher R. Bosse,Maura Diamond,Maura Diamond,Marci Laudenslager,Marci Laudenslager,Cynthia Winter,Cynthia Winter,Jonathan P. Bradfield,Richard H Scott,Jayanti Jagannathan,Maria Garris,Carmel McConville,Wendy B. London,Robert C. Seeger,Struan F.A. Grant,Struan F.A. Grant,Hongzhe Li,Nazneen Rahman,Eric F. Rappaport,Eric F. Rappaport,Hakon Hakonarson,Hakon Hakonarson,John M. Maris,John M. Maris +38 more
TL;DR: In this paper, the authors conducted a genome-wide association study (GWAS) focused on the high-risk subset of neuroblastoma and found significant association with known BARD1 nonsynonymous SNPs.