Thomas R. Müller

TL;DR: In this article , the authors report that SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against B.1.529.

TL;DR: In this article , the authors assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies.

TL;DR: In this paper , SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against B.1.1 .

TL;DR: By studying 51 different TCRs, it is shown that conventional genetic engineering by viral transduction leads to variable TCR expression and T cell product functionality as a result of interference with the endogenous TCR, variable transgene copy numbers, and untargeted transg Gene editing enables defined, targeted TCR insertion with concomitant knockout of the endogenous receptor.

TL;DR: Fogg et al. as mentioned in this paper found that SARS-CoV-2 mRNA vaccines in immunocompromised individuals exhibited robust and persistent Omicron-reactive T cell responses that increased markedly upon booster vaccination and correlated directly with antibody titers across all patient groups.