Caroline Boulouis

TL;DR: It is shown that the two MAIT cell subsets express divergent transcriptional programs and distinct patterns of classic T cell transcription factors and that during development in human fetal tissues, DN MAIT cells are more mature and accumulate over gestational time with reciprocal contraction of the CD8+ subset.

TL;DR: It is shown that MAIT cells mediate MR1-restricted antimicrobial activity against Escherichia coli clinical strains in a manner dependent on the activity of cytolytic proteins but independent of production of pro-inflammatory cytokines or induction of apoptosis in infected cells, and that granulysin and granzyme B synergize to restore carbapenem bactericidal activity and overcome carbAPenem resistance in E. coli.

TL;DR: In this article, the authors developed robust and effective methodology for the expansion of human mucosa-associated invariant T (MAIT) cells with enhanced cytolytic capacity and for their engineering with a new specificity.

TL;DR: In this article , the authors assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies.

TL;DR: Recent findings indicating that MAIT cells display microbe-specific response patterns with multiple layers of heterogeneity deepen the understanding of MAIT cell functional diversity and adaptation to the type and location of microbial challenge.