T
Takuya Sekine
Researcher at Karolinska Institutet
Publications - 18
Citations - 2201
Takuya Sekine is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 7, co-authored 13 publications receiving 1247 citations. Previous affiliations of Takuya Sekine include Karolinska University Hospital.
Papers
More filters
Journal ArticleDOI
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Lars Eriksson,Jan-Inge Henter,Anders Sönnerborg,Tobias Allander,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +29 more
TL;DR: It is shown that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Posted ContentDOI
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean-Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Olav Rooyackers,Lars Eriksson,Lars Eriksson,Anders Sönnerborg,Tobias Allander,Tobias Allander,Jan Albert,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +32 more
TL;DR: The collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses akin to those observed in the context of successful vaccines, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals.
Journal ArticleDOI
MAIT cell activation and dynamics associated with COVID-19 disease severity.
Tiphaine Parrot,Jean-Baptiste Gorin,Andrea Ponzetta,Kimia T. Maleki,Tobias Kammann,Johanna Emgård,André Perez-Potti,Takuya Sekine,Olga Rivera-Ballesteros,Sara Gredmark-Russ,Olav Rooyackers,Olav Rooyackers,Elin Folkesson,Elin Folkesson,Lars Eriksson,Lars Eriksson,Anna Norrby-Teglund,Hans-Gustaf Ljunggren,Niklas K. Björkström,Soo Aleman,Soo Aleman,Marcus Buggert,Jonas Klingström,Kristoffer Strålin,Kristoffer Strålin,Johan K. Sandberg +25 more
TL;DR: Findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.
Journal ArticleDOI
TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells
Takuya Sekine,André Perez-Potti,Son Nguyen,Jean-Baptiste Gorin,Vincent H. Wu,Emma Gostick,Sian Llewellyn-Lacey,Quirin Hammer,Sara Falck-Jones,Sindhu Vangeti,Meng Yu,Anna Smed-Sörensen,Ahmed Gaballa,Michael Uhlin,Michael Uhlin,Johan K. Sandberg,Christian Brander,Christian Brander,Piotr Nowak,Paul A. Goepfert,David Price,Michael R. Betts,Marcus Buggert +22 more
TL;DR: It is demonstrated that circulating TOX+ CD8+ T cells exist in most humans, but that TOX is not exclusively associated with exhaustion.
Journal ArticleDOI
Identification of resident memory CD8 + T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue.
Julia Niessl,Takuya Sekine,Joshua Lange,Viktoria Konya,Marianne Forkel,Jovana Maric,Anna Rao,Luca Mazzurana,Efthymia Kokkinou,Whitney Weigel,Sian Llewellyn-Lacey,Emma B. Hodcroft,Emma B. Hodcroft,Annika C. Karlsson,Johan Fehrm,Johan Fehrm,Joar Sundman,Joar Sundman,David Price,Jenny Mjösberg,Danielle Friberg,Marcus Buggert +21 more
TL;DR: In this article, a comprehensive functional and phenotypic analysis of virus-specific T cells in tonsils, a major lymphoid tissue site in the upper respiratory tract, and matched peripheral blood samples obtained from children and adults before the emergence of COVID-19 was performed.