T
Timothy B. Stockwell
Researcher at J. Craig Venter Institute
Publications - 83
Citations - 22387
Timothy B. Stockwell is an academic researcher from J. Craig Venter Institute. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 38, co-authored 83 publications receiving 21103 citations. Previous affiliations of Timothy B. Stockwell include Celera Corporation.
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Journal ArticleDOI
The early diversification of influenza A/H1N1pdm.
Martha I. Nelson,David J. Spiro,David E. Wentworth,Eric T. Beck,Jiang Fan,Elodie Ghedin,Rebecca A. Halpin,Jayati Bera,Erin Hine,Kathleen Proudfoot,Timothy B. Stockwell,Xudong Lin,Sara Griesemer,Swati Kumar,Michael E. Bose,Cécile Viboud,Edward C. Holmes,Kelly J. Henrickson +17 more
TL;DR: The results indicate that H1N1pdm has already diversified into distinct viral lineages with defined spatial patterns, and is central to understanding the evolution and spatial spread of the current pandemic and to predict its future impact on human populations.
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The soft palate is an important site of adaptation for transmissible influenza viruses
Seema S. Lakdawala,Seema S. Lakdawala,Akila Jayaraman,Rebecca A. Halpin,Elaine W. Lamirande,Angela R. Shih,Timothy B. Stockwell,Xudong Lin,Ari Simenauer,Christopher T. Hanson,Leatrice Vogel,Myeisha Paskel,Mahnaz Minai,Ian N. Moore,Marlene Orandle,Marlene Orandle,Suman R. Das,David E. Wentworth,David E. Wentworth,Ram Sasisekharan,Kanta Subbarao +20 more
TL;DR: It is demonstrated that the ferret soft palate, a tissue not normally sampled in animal models of influenza, rapidly selects for transmissible influenza A viruses with human receptor (α2,6-linked sialic acids) preference.
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Deep Sequencing Reveals Mixed Infection with 2009 Pandemic Influenza A (H1N1) Virus Strains and the Emergence of Oseltamivir Resistance
Elodie Ghedin,Elodie Ghedin,Jennifer Laplante,Jay V. DePasse,David E. Wentworth,David E. Wentworth,Roberto P. Santos,M. L. Lepow,Joanne Porter,Kathleen A. Stellrecht,Xudong Lin,Darwin J. Operario,Sara B. Griesemer,Adam Fitch,Rebecca A. Halpin,Timothy B. Stockwell,David J. Spiro,Edward C. Holmes,Edward C. Holmes,Kirsten St. George +19 more
TL;DR: This patient harbored 3 genetic variants from 2 phylogenetically distinct viral clades of pandemic H1N1/2009, strongly suggestive of mixed infection, and one of these variants also developed drug resistance de novo in response to oseltamivir treatment.
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Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification.
Ashley Sobel Leonard,Micah T. McClain,Gavin J. D. Smith,David E. Wentworth,Rebecca A. Halpin,Xudong Lin,Amy Ransier,Timothy B. Stockwell,Suman R. Das,Anthony Gilbert,Rob Lambkin-Williams,Geoffrey S. Ginsburg,Christopher W. Woods,Katia Koelle +13 more
TL;DR: F influenza virus sequences from a human challenge experiment that initiated infection with a cell- and egg-passaged viral stock appear to have adapted during its preparation, indicating that influenza virus populations can undergo rapid genetic changes during acute human infections.
Journal ArticleDOI
Universal Influenza B Virus Genomic Amplification Facilitates Sequencing, Diagnostics, and Reverse Genetics
Bin Zhou,Xudong Lin,Wei Wang,Rebecca A. Halpin,Jayati Bera,Timothy B. Stockwell,Ian G. Barr,David E. Wentworth +7 more
TL;DR: Special terminal sequences engineered into the optimized IBV-GA2 products enable ligation-free cloning to rapidly generate reverse-genetics plasmids, which can be used for the rescue of recombinant viruses and/or the creation of vaccine seed stock.