T
Timothy Lynagh
Researcher at University of Copenhagen
Publications - 38
Citations - 1069
Timothy Lynagh is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Ion channel & Acid-sensing ion channel. The author has an hindex of 16, co-authored 33 publications receiving 842 citations. Previous affiliations of Timothy Lynagh include University of Queensland & Technische Universität Darmstadt.
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Journal ArticleDOI
Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear.
Roger Marek,Jingji Jin,Travis D. Goode,Thomas F. Giustino,Qian Wang,Gillian M. Acca,Roopashri Holehonnur,Jonathan E. Ploski,Paul J. Fitzgerald,Timothy Lynagh,Joseph W. Lynch,Stephen Maren,Pankaj Sah +12 more
TL;DR: These findings indicate that vHPC-mediated inhibition of IL is an essential neural substrate for fear relapse, and describe a previously unknown circuit mechanism for the contextual control of fear.
Journal ArticleDOI
A hypothalamic circuit for the circadian control of aggression.
William D. Todd,Henning Fenselau,Henning Fenselau,Joshua L. Wang,Rong Zhang,Rong Zhang,Natalia L. S. Machado,Natalia L. S. Machado,Anne Venner,Rebecca Y. Broadhurst,Satvinder Kaur,Timothy Lynagh,David P. Olson,Bradford B. Lowell,Patrick M. Fuller,Clifford B. Saper +15 more
TL;DR: A daily rhythm in aggression propensity in male mice is demonstrated and a novel polysynaptic circuit within the hypothalamus by which the central circadian clock influences neurons that regulate attack behavior is revealed.
Journal ArticleDOI
Ivermectin binding sites in human and invertebrate Cys-loop receptors.
Timothy Lynagh,Joseph W. Lynch +1 more
TL;DR: An understanding of the molecular structure of the ivermectin binding site, which is formed at the interface of two adjacent subunits in the transmembrane domain of the receptor, should aid the development of new lead compounds both as anthelmintics and as therapies for a wide variety of human neurological disorders.
Journal ArticleDOI
An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations
Timothy Lynagh,Joseph W. Lynch +1 more
TL;DR: The development of a modified human α1 glycine receptor as an improved ivermectin-gated silencing receptor is described, the crucial development was the identification of a mutation, A288G, which increased iverMectin sensitivity almost 100-fold, rendering it similar to that of GluClR.
Journal ArticleDOI
A selectivity filter at the intracellular end of the acid-sensing ion channel pore.
Timothy Lynagh,Emelie Flood,Céline Boiteux,Matthias Wulf,Vitaly V. Komnatnyy,Janne M. Colding,Toby W. Allen,Stephan A. Pless +7 more
TL;DR: The basis for ion selectivity in ASICs is explored by incorporating unnatural amino acids into the channel, engineering channel stoichiometry and performing free energy simulations, which identified a band of glutamate and aspartate side chains at the lower end of the pore that enables preferential sodium conduction.