T
Ting-Lin B. Yang
Researcher at Washington University in St. Louis
Publications - 19
Citations - 930
Ting-Lin B. Yang is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Immunology & Medicine. The author has an hindex of 10, co-authored 15 publications receiving 638 citations. Previous affiliations of Ting-Lin B. Yang include University of Pennsylvania & Children's Hospital of Philadelphia.
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Journal ArticleDOI
Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and β-Cell Death
Dan S. Luciani,Kamila S. Gwiazda,Ting-Lin B. Yang,Tatyana B. Kalynyak,Yaryna Bychkivska,Matthew H.Z. Frey,Kristin D. Jeffrey,Arthur V. Sampaio,T. Michael Underhill,James D. Johnson +9 more
TL;DR: It is demonstrated that the activity of ER Ca2+ channels regulates the susceptibility of β-cells to ER stress resulting from impaired SERCA function, and the involvement of mitochondria in β-cell apoptosis associated with dysfunctional β- cell ER Ca1+ homeostasis and ER stress is suggested.
Journal ArticleDOI
EFFECTS OF PALMITATE ON ER AND CYTOSOLIC CA2+ HOMEOSTASIS IN β-CELLS
TL;DR: Ca2+-dependent mechanisms involved in altered beta-cell function and survival induced by the free fatty acid palmitate are characterized and shed light on pathways involved in lipotoxicity and the pathogenesis of type 2 diabetes.
Journal ArticleDOI
HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci.
Katherine M. Aird,Osamu Iwasaki,Andrew V. Kossenkov,Hideki Tanizawa,Nail Fatkhutdinov,Nail Fatkhutdinov,Benjamin G. Bitler,Linh Le,Linh Le,Gretchen M. Alicea,Ting-Lin B. Yang,F. Brad Johnson,Ken-ichi Noma,Rugang Zhang +13 more
TL;DR: It is shown that the chromatin-bound protein HMGB2 orchestrates the SASP by preventing heterochromatin spreading to these specific loci.
Journal ArticleDOI
A basophil-neuronal axis promotes itch
Fang Wang,Fang Wang,Anna M. Trier,Fengxian Li,Fengxian Li,Seonyoung Kim,Zhen Chen,Jiani N. Chai,Madison R. Mack,Stephanie A. Morrison,Jennifer D. Hamilton,Jinok Baek,Jinok Baek,Ting-Lin B. Yang,Aaron M. Ver Heul,Amy Z. Xu,Zili Xie,Xintong Dong,Masato Kubo,Hongzhen Hu,Chyi Song Hsieh,Xinzhong Dong,Qin Liu,David J. Margolis,Marius Ardeleanu,Mark J. Miller,Brian S. Kim +26 more
TL;DR: In this paper, the authors identify that a large proportion of patients with atopic dermatitis harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares.
Journal ArticleDOI
Pruritus in allergy and immunology
Ting-Lin B. Yang,Brian S. Kim +1 more
TL;DR: Recent advances in itch biology have provided critical new insight into a variety of novel therapeutic avenues for chronic itch in the setting of a number of allergic disorders, and it is highlighted how these new developments will likely inform the problem of pruritus in a range of well-established and emerging conditions in the field of allergy.